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Discovering novel brain lipids by liquid chromatography/tandem mass spectrometry.

Publication ,  Journal Article
Guan, Z
Published in: J Chromatogr B Analyt Technol Biomed Life Sci
September 15, 2009

Discovery and structural elucidation of novel brain lipids hold great promise in revealing new lipid functions in the brain and in understanding the biochemical mechanisms underlying brain physiology and pathology. The revived interests in searching for novel brain lipids have been stimulated by the expanding knowledge of the roles of lipids in brain functions, lipids acting as signaling molecules, and the advent of lipidomics enabled by the advances in mass spectrometry (MS) and liquid chromatography (LC). The identification and characterization of two classes of novel lipids from the brain are reviewed here: N-acyl phosphatidylserine (N-acyl-PS) and dolichoic acid (Dol-CA). The identification of these lipids benefited from the use of efficient lipid fractionation and separation techniques and highly sensitive, high-resolution tandem MS.

Duke Scholars

Published In

J Chromatogr B Analyt Technol Biomed Life Sci

DOI

EISSN

1873-376X

Publication Date

September 15, 2009

Volume

877

Issue

26

Start / End Page

2814 / 2821

Location

Netherlands

Related Subject Headings

  • Tandem Mass Spectrometry
  • Lipids
  • Lipid Metabolism
  • Humans
  • Chromatography, Liquid
  • Brain Chemistry
  • Brain
  • Animals
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0601 Biochemistry and Cell Biology
 

Citation

APA
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ICMJE
MLA
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Guan, Z. (2009). Discovering novel brain lipids by liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci, 877(26), 2814–2821. https://doi.org/10.1016/j.jchromb.2009.03.002
Guan, Ziqiang. “Discovering novel brain lipids by liquid chromatography/tandem mass spectrometry.J Chromatogr B Analyt Technol Biomed Life Sci 877, no. 26 (September 15, 2009): 2814–21. https://doi.org/10.1016/j.jchromb.2009.03.002.
Guan Z. Discovering novel brain lipids by liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2814–21.
Guan, Ziqiang. “Discovering novel brain lipids by liquid chromatography/tandem mass spectrometry.J Chromatogr B Analyt Technol Biomed Life Sci, vol. 877, no. 26, Sept. 2009, pp. 2814–21. Pubmed, doi:10.1016/j.jchromb.2009.03.002.
Guan Z. Discovering novel brain lipids by liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2814–2821.
Journal cover image

Published In

J Chromatogr B Analyt Technol Biomed Life Sci

DOI

EISSN

1873-376X

Publication Date

September 15, 2009

Volume

877

Issue

26

Start / End Page

2814 / 2821

Location

Netherlands

Related Subject Headings

  • Tandem Mass Spectrometry
  • Lipids
  • Lipid Metabolism
  • Humans
  • Chromatography, Liquid
  • Brain Chemistry
  • Brain
  • Animals
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0601 Biochemistry and Cell Biology