Isolation, structure, and coccidiostat activity of coccidiostatin A.
Publication
, Journal Article
Jayasuriya, H; Guan, Z; Dombrowski, AW; Bills, GF; Polishook, JD; Jenkins, RG; Koch, L; Crumley, T; Tamas, T; Dubois, M; Misura, A; Gregory, L ...
Published in: J Nat Prod
August 2007
Coccidiosis is one of the more common and costly diseases in poultry that is caused by various Eimeria species. In our quest to discover coccidiostats from natural products, we discovered a microbial fermentation extract that exhibited in vivo anticoccidial activity. Fractionation of this extract led to the discovery of two potent antiprotozoals, emecorrugatin A (1) and coccidiostatin A (2). The former compound exhibited only in vitro activity, whereas the latter new compound exhibited in vivo activity against Eimeria species in chickens at 150 ppm dosed in chicken feed. The isolation, structure elucidation, relative configuration, and activity of coccidiostatin A (2) are described.
Duke Scholars
Published In
J Nat Prod
DOI
ISSN
0163-3864
Publication Date
August 2007
Volume
70
Issue
8
Start / End Page
1364 / 1367
Location
United States
Related Subject Headings
- Penicillium
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Heterocyclic Compounds, Bridged-Ring
- Eimeria
- Coccidiostats
- Coccidiosis
- Animals
- 4208 Traditional, complementary and integrative medicine
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Jayasuriya, H., Guan, Z., Dombrowski, A. W., Bills, G. F., Polishook, J. D., Jenkins, R. G., … Singh, S. B. (2007). Isolation, structure, and coccidiostat activity of coccidiostatin A. J Nat Prod, 70(8), 1364–1367. https://doi.org/10.1021/np0700523
Jayasuriya, Hiranthi, Ziqiang Guan, Anne W. Dombrowski, Gerald F. Bills, Jon D. Polishook, Rosalind G. Jenkins, Leslie Koch, et al. “Isolation, structure, and coccidiostat activity of coccidiostatin A.” J Nat Prod 70, no. 8 (August 2007): 1364–67. https://doi.org/10.1021/np0700523.
Jayasuriya H, Guan Z, Dombrowski AW, Bills GF, Polishook JD, Jenkins RG, et al. Isolation, structure, and coccidiostat activity of coccidiostatin A. J Nat Prod. 2007 Aug;70(8):1364–7.
Jayasuriya, Hiranthi, et al. “Isolation, structure, and coccidiostat activity of coccidiostatin A.” J Nat Prod, vol. 70, no. 8, Aug. 2007, pp. 1364–67. Pubmed, doi:10.1021/np0700523.
Jayasuriya H, Guan Z, Dombrowski AW, Bills GF, Polishook JD, Jenkins RG, Koch L, Crumley T, Tamas T, Dubois M, Misura A, Darkin-Rattray SJ, Gregory L, Singh SB. Isolation, structure, and coccidiostat activity of coccidiostatin A. J Nat Prod. 2007 Aug;70(8):1364–1367.
Published In
J Nat Prod
DOI
ISSN
0163-3864
Publication Date
August 2007
Volume
70
Issue
8
Start / End Page
1364 / 1367
Location
United States
Related Subject Headings
- Penicillium
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Heterocyclic Compounds, Bridged-Ring
- Eimeria
- Coccidiostats
- Coccidiosis
- Animals
- 4208 Traditional, complementary and integrative medicine
- 11 Medical and Health Sciences