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Isolation and insecticidal/anthelmintic activity of xanthonol, a novel bis-xanthone, from a non-sporulating fungal species.

Publication ,  Journal Article
Ondeyka, JG; Dombrowski, AW; Polishook, JP; Felcetto, T; Shoop, WL; Guan, Z; Singh, SB
Published in: J Antibiot (Tokyo)
May 2006
Published version (DOI) Link to item

Xanthonol, a novel dimeric xanthone, was isolated from a fermentation broth of a non-sporulating fungal species using Sephadex LH20 followed by HPLC and the structure elucidated by spectral analysis. Xanthonol exhibited insecticidal and anthelmintic activities against larvae of Lucilia sericata, Aedes aegypti, and Haemonchus contortus with LD90 of 33, 8, and 50 microg/ml, respectively.

Duke Scholars

Ziqiang Guan
Author Ziqiang Guan Biochemistry

Published In

J Antibiot (Tokyo)

DOI

10.1038/ja.2006.40

ISSN

0021-8820

Publication Date

May 2006

Volume

59

Issue

5

Start / End Page

288 / 292

Location

England

Related Subject Headings

  • Xanthones
  • Spectrometry, Mass, Electrospray Ionization
  • Optical Rotation
  • Nuclear Magnetic Resonance, Biomolecular
  • Molecular Structure
  • Microbiology
  • Medicinal & Biomolecular Chemistry
  • Insecticides
  • Gas Chromatography-Mass Spectrometry
  • Fungi
 

Citation

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MLA
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Ondeyka, J. G., Dombrowski, A. W., Polishook, J. P., Felcetto, T., Shoop, W. L., Guan, Z., & Singh, S. B. (2006). Isolation and insecticidal/anthelmintic activity of xanthonol, a novel bis-xanthone, from a non-sporulating fungal species. J Antibiot (Tokyo), 59(5), 288–292. https://doi.org/10.1038/ja.2006.40
Ondeyka, John G., Anne W. Dombrowski, Jon P. Polishook, Tom Felcetto, Wesley L. Shoop, Ziqiang Guan, and Sheo B. Singh. “Isolation and insecticidal/anthelmintic activity of xanthonol, a novel bis-xanthone, from a non-sporulating fungal species.” J Antibiot (Tokyo) 59, no. 5 (May 2006): 288–92. https://doi.org/10.1038/ja.2006.40.
Ondeyka JG, Dombrowski AW, Polishook JP, Felcetto T, Shoop WL, Guan Z, et al. Isolation and insecticidal/anthelmintic activity of xanthonol, a novel bis-xanthone, from a non-sporulating fungal species. J Antibiot (Tokyo). 2006 May;59(5):288–92.
Ondeyka, John G., et al. “Isolation and insecticidal/anthelmintic activity of xanthonol, a novel bis-xanthone, from a non-sporulating fungal species.” J Antibiot (Tokyo), vol. 59, no. 5, May 2006, pp. 288–92. Pubmed, doi:10.1038/ja.2006.40.
Ondeyka JG, Dombrowski AW, Polishook JP, Felcetto T, Shoop WL, Guan Z, Singh SB. Isolation and insecticidal/anthelmintic activity of xanthonol, a novel bis-xanthone, from a non-sporulating fungal species. J Antibiot (Tokyo). 2006 May;59(5):288–292.

Published In

J Antibiot (Tokyo)

DOI

10.1038/ja.2006.40

ISSN

0021-8820

Publication Date

May 2006

Volume

59

Issue

5

Start / End Page

288 / 292

Location

England

Related Subject Headings

  • Xanthones
  • Spectrometry, Mass, Electrospray Ionization
  • Optical Rotation
  • Nuclear Magnetic Resonance, Biomolecular
  • Molecular Structure
  • Microbiology
  • Medicinal & Biomolecular Chemistry
  • Insecticides
  • Gas Chromatography-Mass Spectrometry
  • Fungi