Isolation, structure, and HIV-1 integrase inhibitory activity of Cytosporic acid, a fungal metabolite produced by a Cytospora sp.
Publication
, Journal Article
Jayasuriya, H; Guan, Z; Polishook, JD; Dombrowski, AW; Felock, PJ; Hazuda, DJ; Singh, SB
Published in: J Nat Prod
April 2003
HIV-1 integrase is a critical enzyme for replication of HIV, and its inhibition has the potential to lead to an anti-retroviral therapy that has advantages over existing therapies. Cytosporic acid (1) is a polyketide-derived novel natural product that was isolated from a fermentation broth of the filamentous fungus Cytospora sp. collected from Puerto Rico. It inhibited strand transfer reaction of HIV-1 integrase with an IC(50) of 20 microM. The isolation, structure elucidation, relative stereochemistry, and activity of 1 are described.
Duke Scholars
Published In
J Nat Prod
DOI
ISSN
0163-3864
Publication Date
April 2003
Volume
66
Issue
4
Start / End Page
551 / 553
Location
United States
Related Subject Headings
- Tetrahydronaphthalenes
- Stereoisomerism
- Puerto Rico
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Inhibitory Concentration 50
- HIV-1
- HIV Integrase Inhibitors
- Fungi
- Fermentation
Citation
APA
Chicago
ICMJE
MLA
NLM
Jayasuriya, H., Guan, Z., Polishook, J. D., Dombrowski, A. W., Felock, P. J., Hazuda, D. J., & Singh, S. B. (2003). Isolation, structure, and HIV-1 integrase inhibitory activity of Cytosporic acid, a fungal metabolite produced by a Cytospora sp. J Nat Prod, 66(4), 551–553. https://doi.org/10.1021/np020533g
Jayasuriya, Hiranthi, Ziqiang Guan, Jon D. Polishook, Anne W. Dombrowski, Peter J. Felock, Daria J. Hazuda, and Sheo B. Singh. “Isolation, structure, and HIV-1 integrase inhibitory activity of Cytosporic acid, a fungal metabolite produced by a Cytospora sp.” J Nat Prod 66, no. 4 (April 2003): 551–53. https://doi.org/10.1021/np020533g.
Jayasuriya H, Guan Z, Polishook JD, Dombrowski AW, Felock PJ, Hazuda DJ, et al. Isolation, structure, and HIV-1 integrase inhibitory activity of Cytosporic acid, a fungal metabolite produced by a Cytospora sp. J Nat Prod. 2003 Apr;66(4):551–3.
Jayasuriya, Hiranthi, et al. “Isolation, structure, and HIV-1 integrase inhibitory activity of Cytosporic acid, a fungal metabolite produced by a Cytospora sp.” J Nat Prod, vol. 66, no. 4, Apr. 2003, pp. 551–53. Pubmed, doi:10.1021/np020533g.
Jayasuriya H, Guan Z, Polishook JD, Dombrowski AW, Felock PJ, Hazuda DJ, Singh SB. Isolation, structure, and HIV-1 integrase inhibitory activity of Cytosporic acid, a fungal metabolite produced by a Cytospora sp. J Nat Prod. 2003 Apr;66(4):551–553.
Published In
J Nat Prod
DOI
ISSN
0163-3864
Publication Date
April 2003
Volume
66
Issue
4
Start / End Page
551 / 553
Location
United States
Related Subject Headings
- Tetrahydronaphthalenes
- Stereoisomerism
- Puerto Rico
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Inhibitory Concentration 50
- HIV-1
- HIV Integrase Inhibitors
- Fungi
- Fermentation