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Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system?

Publication ,  Journal Article
Guilak, F; Leddy, HA; Liedtke, W
Published in: Ann N Y Acad Sci
March 2010

The critical discovery in the past two decades of the transient receptor potential (TRP) superfamily of ion channels has revealed the potential mechanisms by which cells sense diverse stimuli beyond the prototypical "five senses," identifying ion channels that are gated by heat, cold, mechanical loading, osmolarity, and other physical and chemical stimuli. TRP vanilloid 4 (TRPV4) is a Ca(2+)-permeable nonselective cation channel that appears to play a mechanosensory or osmosensory role in several musculoskeletal tissues. In articular cartilage, TRPV4 exhibits osmotic sensitivity, controlling cellular volume recovery, and other physiologic responses to osmotic stress. TRPV4 is expressed in both osteoblasts and osteoclasts, and the absence of TRPV4 prevents disuse-induced bone loss. TRPV4 activation promotes chondrogenesis by inducing SOX9 transcription, whereas a TRPV4 gain-of-function mutation leads to a developmental skeletal dysplasia, suggesting a critical role for TRPV4 in skeletal development. These studies provide mounting evidence for a regulatory role for the sensory channel TRPV4 in control of musculoskeletal tissues.

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Published In

Ann N Y Acad Sci

DOI

EISSN

1749-6632

Publication Date

March 2010

Volume

1192

Start / End Page

404 / 409

Location

United States

Related Subject Headings

  • Transient Receptor Potential Channels
  • TRPV Cation Channels
  • Osmosis
  • Musculoskeletal System
  • Mechanotransduction, Cellular
  • Humans
  • General Science & Technology
  • Bone and Bones
  • Animals
 

Citation

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Guilak, F., Leddy, H. A., & Liedtke, W. (2010). Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system? Ann N Y Acad Sci, 1192, 404–409. https://doi.org/10.1111/j.1749-6632.2010.05389.x
Guilak, Farshid, Holly A. Leddy, and Wolfgang Liedtke. “Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system?Ann N Y Acad Sci 1192 (March 2010): 404–9. https://doi.org/10.1111/j.1749-6632.2010.05389.x.
Guilak F, Leddy HA, Liedtke W. Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system? Ann N Y Acad Sci. 2010 Mar;1192:404–9.
Guilak, Farshid, et al. “Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system?Ann N Y Acad Sci, vol. 1192, Mar. 2010, pp. 404–09. Pubmed, doi:10.1111/j.1749-6632.2010.05389.x.
Guilak F, Leddy HA, Liedtke W. Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system? Ann N Y Acad Sci. 2010 Mar;1192:404–409.
Journal cover image

Published In

Ann N Y Acad Sci

DOI

EISSN

1749-6632

Publication Date

March 2010

Volume

1192

Start / End Page

404 / 409

Location

United States

Related Subject Headings

  • Transient Receptor Potential Channels
  • TRPV Cation Channels
  • Osmosis
  • Musculoskeletal System
  • Mechanotransduction, Cellular
  • Humans
  • General Science & Technology
  • Bone and Bones
  • Animals