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Control of stem cell fate by physical interactions with the extracellular matrix.

Publication ,  Journal Article
Guilak, F; Cohen, DM; Estes, BT; Gimble, JM; Liedtke, W; Chen, CS
Published in: Cell Stem Cell
July 2, 2009

A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at the nanoscale, ECM mechanical properties, and the transmission of mechanical or other biophysical factors to the cell. Here, we review some of the physical processes by which cues from the ECM can influence stem cell fate, with particular relevance to the use of stem cells in tissue engineering and regenerative medicine.

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Published In

Cell Stem Cell

DOI

EISSN

1875-9777

Publication Date

July 2, 2009

Volume

5

Issue

1

Start / End Page

17 / 26

Location

United States

Related Subject Headings

  • Tissue Engineering
  • Stem Cells
  • Signal Transduction
  • Regenerative Medicine
  • Extracellular Matrix
  • Developmental Biology
  • Cell Shape
  • Cell Differentiation
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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Guilak, F., Cohen, D. M., Estes, B. T., Gimble, J. M., Liedtke, W., & Chen, C. S. (2009). Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell, 5(1), 17–26. https://doi.org/10.1016/j.stem.2009.06.016
Guilak, Farshid, Daniel M. Cohen, Bradley T. Estes, Jeffrey M. Gimble, Wolfgang Liedtke, and Christopher S. Chen. “Control of stem cell fate by physical interactions with the extracellular matrix.Cell Stem Cell 5, no. 1 (July 2, 2009): 17–26. https://doi.org/10.1016/j.stem.2009.06.016.
Guilak F, Cohen DM, Estes BT, Gimble JM, Liedtke W, Chen CS. Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell. 2009 Jul 2;5(1):17–26.
Guilak, Farshid, et al. “Control of stem cell fate by physical interactions with the extracellular matrix.Cell Stem Cell, vol. 5, no. 1, July 2009, pp. 17–26. Pubmed, doi:10.1016/j.stem.2009.06.016.
Guilak F, Cohen DM, Estes BT, Gimble JM, Liedtke W, Chen CS. Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell. 2009 Jul 2;5(1):17–26.
Journal cover image

Published In

Cell Stem Cell

DOI

EISSN

1875-9777

Publication Date

July 2, 2009

Volume

5

Issue

1

Start / End Page

17 / 26

Location

United States

Related Subject Headings

  • Tissue Engineering
  • Stem Cells
  • Signal Transduction
  • Regenerative Medicine
  • Extracellular Matrix
  • Developmental Biology
  • Cell Shape
  • Cell Differentiation
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences