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Adherent biofilms in bacterial vaginosis

Publication ,  Journal Article
Swidsinski, A; Mendling, W; Loening-Baucke, V; Ladhoff, A; Swidsinski, S; Hale, LP; Lochs, H
Published in: Obstetrics and Gynecology
2005

OBJECTIVE: Bacterial vaginosis is a common infectious disorder. Although known since ancient times, little progress has occurred in identifying causal factors. Our aims were to study the bacterial community structure and the spatial organization of microbiota on the epithelial surfaces of vaginal biopsy specimens. METHODS: We investigated the composition and spatial organization of bacteria associated with the vaginal epithelium in biopsy specimens from 20 patients with bacterial vaginosis and 40 normal premenopausal and postmenopausal controls using a broad range of fluorescent bacterial group-specific rRNA-targeted oligonucleotide probes. RESULTS: Bacterial vaginosis was associated with greater occurrence and higher concentrations of a variety of bacterial groups. However, only Gardnerella vaginalis developed a characteristic adherent biofilm that was specific for bacterial vaginosis. CONCLUSION: A biofilm comprised of confluent G vaginalis with other bacterial groups incorporated in the adherent layer is a prominent feature of bacterial vaginosis. © 2005 by The American College of Obstetricians and Gynecologists. Published by Lippincott Williams & Wilkins.

Duke Scholars

Published In

Obstetrics and Gynecology

ISSN

0029-7844

Publication Date

2005

Volume

106

Issue

5 I

Start / End Page

1013 / 1023

Related Subject Headings

  • Obstetrics & Reproductive Medicine
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

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Chicago
ICMJE
MLA
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Swidsinski, A., Mendling, W., Loening-Baucke, V., Ladhoff, A., Swidsinski, S., Hale, L. P., & Lochs, H. (2005). Adherent biofilms in bacterial vaginosis. Obstetrics and Gynecology, 106(5 I), 1013–1023.
Swidsinski, A., W. Mendling, V. Loening-Baucke, A. Ladhoff, S. Swidsinski, L. P. Hale, and H. Lochs. “Adherent biofilms in bacterial vaginosis.” Obstetrics and Gynecology 106, no. 5 I (2005): 1013–23.
Swidsinski A, Mendling W, Loening-Baucke V, Ladhoff A, Swidsinski S, Hale LP, et al. Adherent biofilms in bacterial vaginosis. Obstetrics and Gynecology. 2005;106(5 I):1013–23.
Swidsinski, A., et al. “Adherent biofilms in bacterial vaginosis.” Obstetrics and Gynecology, vol. 106, no. 5 I, 2005, pp. 1013–23.
Swidsinski A, Mendling W, Loening-Baucke V, Ladhoff A, Swidsinski S, Hale LP, Lochs H. Adherent biofilms in bacterial vaginosis. Obstetrics and Gynecology. 2005;106(5 I):1013–1023.
Journal cover image

Published In

Obstetrics and Gynecology

ISSN

0029-7844

Publication Date

2005

Volume

106

Issue

5 I

Start / End Page

1013 / 1023

Related Subject Headings

  • Obstetrics & Reproductive Medicine
  • 1114 Paediatrics and Reproductive Medicine