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Pathology of parainfluenza virus infection in patients with congenital immunodeficiency syndromes.

Publication ,  Journal Article
Madden, JF; Burchette, JL; Hale, LP
Published in: Hum Pathol
May 2004

Infection with parainfluenza virus typically produces a mild, self-limited upper respiratory infection. However, parainfluenza infections have become increasingly recognized as a source of severe morbidity and mortality in immunocompromised patients. In this retrospective study we identified 6 patients with congenital immunodeficiency and positive respiratory cultures for parainfluenza virus who died and underwent complete autopsy. Tissues obtained at autopsy were studied using hematoxylin and eosin-stained sections, immunoperoxidase staining for parainfluenza virus, and in selected cases, electron microscopy. All 6 patients exhibited typical cytopathic effects of parainfluenza virus, including giant cell formation, in lung and/or bronchial tissues. Parainfluenza virus infection was also documented by giant cell formation and immunohistochemistry in the pancreas (in 3 of 6 patients) and the kidney or bladder (in 2 of 4 patients). Anti-parainfluenza antibody also specifically reacted with cells in the gastrointestinal tract (in 2 of 4), spleen (in 4 of 6), thymus and/or lymph nodes (in 4 of 4), and small blood vessels in various organs (in 4 of 6). Pancreatic, bladder, colon, and thymic epithelial cell lines were susceptible to experimental infections with clinical isolates of parainfluenza virus type 3 in vitro. Parainfluenza virus infection was serious in patients with congenital immunodeficiencies, contributing directly to death in 5 of the 6 patients studied. Because this virus is capable of infecting tissues in the gastrointestinal and urinary systems as well as in the respiratory tract, body secretions and fluids from each of these locations should be considered potentially infectious.

Duke Scholars

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

May 2004

Volume

35

Issue

5

Start / End Page

594 / 603

Location

United States

Related Subject Headings

  • Urinary Bladder
  • Retrospective Studies
  • Pathology
  • Paramyxoviridae Infections
  • Pancreas
  • Microscopy, Electron
  • Male
  • Lung
  • Kidney
  • Infant
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Madden, J. F., Burchette, J. L., & Hale, L. P. (2004). Pathology of parainfluenza virus infection in patients with congenital immunodeficiency syndromes. Hum Pathol, 35(5), 594–603. https://doi.org/10.1016/j.humpath.2003.11.012
Madden, John F., James L. Burchette, and Laura P. Hale. “Pathology of parainfluenza virus infection in patients with congenital immunodeficiency syndromes.Hum Pathol 35, no. 5 (May 2004): 594–603. https://doi.org/10.1016/j.humpath.2003.11.012.
Madden JF, Burchette JL, Hale LP. Pathology of parainfluenza virus infection in patients with congenital immunodeficiency syndromes. Hum Pathol. 2004 May;35(5):594–603.
Madden, John F., et al. “Pathology of parainfluenza virus infection in patients with congenital immunodeficiency syndromes.Hum Pathol, vol. 35, no. 5, May 2004, pp. 594–603. Pubmed, doi:10.1016/j.humpath.2003.11.012.
Madden JF, Burchette JL, Hale LP. Pathology of parainfluenza virus infection in patients with congenital immunodeficiency syndromes. Hum Pathol. 2004 May;35(5):594–603.
Journal cover image

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

May 2004

Volume

35

Issue

5

Start / End Page

594 / 603

Location

United States

Related Subject Headings

  • Urinary Bladder
  • Retrospective Studies
  • Pathology
  • Paramyxoviridae Infections
  • Pancreas
  • Microscopy, Electron
  • Male
  • Lung
  • Kidney
  • Infant