Prognostic modeling in early stage lung cancer: an evolving process from histopathology to genomics.
Publication
, Journal Article
Harpole, DH
Published in: Thorac Surg Clin
May 2007
The goal is to validate a molecular-based tumor model that identifies patients at low-risk for cancer recurrence and who will not benefit from adjuvant chemotherapy. The remaining patients will be randomized to observation (present standard of care) or adjuvant chemotherapy to determine efficacy of adjuvant in this population. Investigators have focused on the identification of markers that may predict poor prognosis as a way to "enrich" the population by separating those likely to have early recurrence and cancer death from those not needing additional treatment after resection. The initial projects refined predictive models of cancer recurrence after resection for patients with early stage non-small cell lung cancer.
Duke Scholars
Published In
Thorac Surg Clin
DOI
ISSN
1547-4127
Publication Date
May 2007
Volume
17
Issue
2
Start / End Page
167 / viii
Location
United States
Related Subject Headings
- Respiratory System
- Randomized Controlled Trials as Topic
- Prognosis
- Neoplasm Staging
- Neoplasm Recurrence, Local
- Lung Neoplasms
- Humans
- Genomics
- Carcinoma, Non-Small-Cell Lung
- Biomarkers, Tumor
Citation
APA
Chicago
ICMJE
MLA
NLM
Harpole, D. H. (2007). Prognostic modeling in early stage lung cancer: an evolving process from histopathology to genomics. Thorac Surg Clin, 17(2), 167–viii. https://doi.org/10.1016/j.thorsurg.2007.03.014
Harpole, David H. “Prognostic modeling in early stage lung cancer: an evolving process from histopathology to genomics.” Thorac Surg Clin 17, no. 2 (May 2007): 167–viii. https://doi.org/10.1016/j.thorsurg.2007.03.014.
Harpole DH. Prognostic modeling in early stage lung cancer: an evolving process from histopathology to genomics. Thorac Surg Clin. 2007 May;17(2):167–viii.
Harpole, David H. “Prognostic modeling in early stage lung cancer: an evolving process from histopathology to genomics.” Thorac Surg Clin, vol. 17, no. 2, May 2007, pp. 167–viii. Pubmed, doi:10.1016/j.thorsurg.2007.03.014.
Harpole DH. Prognostic modeling in early stage lung cancer: an evolving process from histopathology to genomics. Thorac Surg Clin. 2007 May;17(2):167–viii.
Published In
Thorac Surg Clin
DOI
ISSN
1547-4127
Publication Date
May 2007
Volume
17
Issue
2
Start / End Page
167 / viii
Location
United States
Related Subject Headings
- Respiratory System
- Randomized Controlled Trials as Topic
- Prognosis
- Neoplasm Staging
- Neoplasm Recurrence, Local
- Lung Neoplasms
- Humans
- Genomics
- Carcinoma, Non-Small-Cell Lung
- Biomarkers, Tumor