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Borg proteins control septin organization and are negatively regulated by Cdc42.

Publication ,  Journal Article
Joberty, G; Perlungher, RR; Sheffield, PJ; Kinoshita, M; Noda, M; Haystead, T; Macara, IG
Published in: Nat Cell Biol
October 2001

The Cdc42 GTPase binds to numerous effector proteins that control cell polarity, cytoskeletal remodelling and vesicle transport. In many cases the signalling pathways downstream of these effectors are not known. Here we show that the Cdc42 effectors Borg1 to Borg3 bind to septin GTPases. Endogenous septin Cdc10 and Borg3 proteins can be immunoprecipitated together by an anti-Borg3 antibody. The ectopic expression of Borgs disrupts normal septin organization. Cdc42 negatively regulates this effect and inhibits the binding of Borg3 to septins. Borgs are therefore the first known regulators of mammalian septin organization and provide an unexpected link between the septin and Cdc42 GTPases.

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Published In

Nat Cell Biol

DOI

ISSN

1465-7392

Publication Date

October 2001

Volume

3

Issue

10

Start / End Page

861 / 866

Location

England

Related Subject Headings

  • rho GTP-Binding Proteins
  • cdc42 GTP-Binding Protein
  • Recombinant Fusion Proteins
  • RNA-Binding Proteins
  • Protein Structure, Tertiary
  • Protein Binding
  • Molecular Sequence Data
  • Microscopy, Fluorescence
  • Mice
  • GTP-Binding Protein Regulators
 

Citation

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Joberty, G., Perlungher, R. R., Sheffield, P. J., Kinoshita, M., Noda, M., Haystead, T., & Macara, I. G. (2001). Borg proteins control septin organization and are negatively regulated by Cdc42. Nat Cell Biol, 3(10), 861–866. https://doi.org/10.1038/ncb1001-861
Joberty, G., R. R. Perlungher, P. J. Sheffield, M. Kinoshita, M. Noda, T. Haystead, and I. G. Macara. “Borg proteins control septin organization and are negatively regulated by Cdc42.Nat Cell Biol 3, no. 10 (October 2001): 861–66. https://doi.org/10.1038/ncb1001-861.
Joberty G, Perlungher RR, Sheffield PJ, Kinoshita M, Noda M, Haystead T, et al. Borg proteins control septin organization and are negatively regulated by Cdc42. Nat Cell Biol. 2001 Oct;3(10):861–6.
Joberty, G., et al. “Borg proteins control septin organization and are negatively regulated by Cdc42.Nat Cell Biol, vol. 3, no. 10, Oct. 2001, pp. 861–66. Pubmed, doi:10.1038/ncb1001-861.
Joberty G, Perlungher RR, Sheffield PJ, Kinoshita M, Noda M, Haystead T, Macara IG. Borg proteins control septin organization and are negatively regulated by Cdc42. Nat Cell Biol. 2001 Oct;3(10):861–866.

Published In

Nat Cell Biol

DOI

ISSN

1465-7392

Publication Date

October 2001

Volume

3

Issue

10

Start / End Page

861 / 866

Location

England

Related Subject Headings

  • rho GTP-Binding Proteins
  • cdc42 GTP-Binding Protein
  • Recombinant Fusion Proteins
  • RNA-Binding Proteins
  • Protein Structure, Tertiary
  • Protein Binding
  • Molecular Sequence Data
  • Microscopy, Fluorescence
  • Mice
  • GTP-Binding Protein Regulators