The role of apoptosis in the development and function of T lymphocytes.
Publication
, Journal Article
Zhang, N; Hartig, H; Dzhagalov, I; Draper, D; He, YW
Published in: Cell Res
October 2005
Apoptosis plays an essential role in T cell biology. Thymocytes expressing nonfunctional or autoreactive TCRs are eliminated by apoptosis during development. Apoptosis also leads to the deletion of expanded effector T cells during immune responses. The dysregulation of apoptosis in the immune system results in autoimmunity, tumorogenesis and immunodeficiency. Two major pathways lead to apoptosis: the intrinsic cell death pathway controlled by Bcl-2 family members and the extrinsic cell death pathway controlled by death receptor signaling. These two pathways work together to regulate T lymphocyte development and function.
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Published In
Cell Res
DOI
ISSN
1001-0602
Publication Date
October 2005
Volume
15
Issue
10
Start / End Page
749 / 769
Location
England
Related Subject Headings
- Thymus Gland
- T-Lymphocytes
- Signal Transduction
- Receptors, Tumor Necrosis Factor
- Proto-Oncogene Proteins c-bcl-2
- Mice
- Developmental Biology
- Apoptosis
- Animals
- 3101 Biochemistry and cell biology
Citation
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ICMJE
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Zhang, N., Hartig, H., Dzhagalov, I., Draper, D., & He, Y. W. (2005). The role of apoptosis in the development and function of T lymphocytes. Cell Res, 15(10), 749–769. https://doi.org/10.1038/sj.cr.7290345
Zhang, Nu, Heather Hartig, Ivan Dzhagalov, David Draper, and You Wen He. “The role of apoptosis in the development and function of T lymphocytes.” Cell Res 15, no. 10 (October 2005): 749–69. https://doi.org/10.1038/sj.cr.7290345.
Zhang N, Hartig H, Dzhagalov I, Draper D, He YW. The role of apoptosis in the development and function of T lymphocytes. Cell Res. 2005 Oct;15(10):749–69.
Zhang, Nu, et al. “The role of apoptosis in the development and function of T lymphocytes.” Cell Res, vol. 15, no. 10, Oct. 2005, pp. 749–69. Pubmed, doi:10.1038/sj.cr.7290345.
Zhang N, Hartig H, Dzhagalov I, Draper D, He YW. The role of apoptosis in the development and function of T lymphocytes. Cell Res. 2005 Oct;15(10):749–769.
Published In
Cell Res
DOI
ISSN
1001-0602
Publication Date
October 2005
Volume
15
Issue
10
Start / End Page
749 / 769
Location
England
Related Subject Headings
- Thymus Gland
- T-Lymphocytes
- Signal Transduction
- Receptors, Tumor Necrosis Factor
- Proto-Oncogene Proteins c-bcl-2
- Mice
- Developmental Biology
- Apoptosis
- Animals
- 3101 Biochemistry and cell biology