Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.
Publication
, Journal Article
Onyewu, C; Afshari, NA; Heitman, J
Published in: Antimicrob Agents Chemother
November 2006
In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.
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Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
November 2006
Volume
50
Issue
11
Start / End Page
3963 / 3965
Location
United States
Related Subject Headings
- Microbiology
- Mice, Inbred BALB C
- Mice
- Keratitis
- Immunosuppressive Agents
- Fluconazole
- Cyclosporine
- Corneal Diseases
- Candidiasis
- Candida albicans
Citation
APA
Chicago
ICMJE
MLA
NLM
Onyewu, C., Afshari, N. A., & Heitman, J. (2006). Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy. Antimicrob Agents Chemother, 50(11), 3963–3965. https://doi.org/10.1128/AAC.00393-06
Onyewu, Chiatogu, Natalie A. Afshari, and Joseph Heitman. “Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.” Antimicrob Agents Chemother 50, no. 11 (November 2006): 3963–65. https://doi.org/10.1128/AAC.00393-06.
Onyewu C, Afshari NA, Heitman J. Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy. Antimicrob Agents Chemother. 2006 Nov;50(11):3963–5.
Onyewu, Chiatogu, et al. “Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.” Antimicrob Agents Chemother, vol. 50, no. 11, Nov. 2006, pp. 3963–65. Pubmed, doi:10.1128/AAC.00393-06.
Onyewu C, Afshari NA, Heitman J. Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy. Antimicrob Agents Chemother. 2006 Nov;50(11):3963–3965.
Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
November 2006
Volume
50
Issue
11
Start / End Page
3963 / 3965
Location
United States
Related Subject Headings
- Microbiology
- Mice, Inbred BALB C
- Mice
- Keratitis
- Immunosuppressive Agents
- Fluconazole
- Cyclosporine
- Corneal Diseases
- Candidiasis
- Candida albicans