Scholars@Duke

Deciphering the model pathogenic fungus Cryptococcus neoformans.

Publication ,  Journal Article
Idnurm, A; Bahn, Y-S; Nielsen, K; Lin, X; Fraser, JA; Heitman, J
Published in: Nat Rev Microbiol
October 2005
Published version (DOI) Link to item

Cryptococcus neoformans is a basidiomycete fungal pathogen of humans that has diverged considerably from other model fungi such as Neurospora crassa, Aspergillus nidulans, Saccharomyces cerevisiae and the common human fungal pathogen Candida albicans. The recent completion of the genome sequences of two related C. neoformans strains and the ongoing genome sequencing of three other divergent Cryptococcus strains with different virulence phenotypes and environmental distributions should improve our understanding of this important pathogen. We discuss the biology of C. neoformans in light of this genomic data, with a special emphasis on the role that evolution and sexual reproduction have in the complex relationships of the fungus with the environment and the host.

Duke Scholars

Joseph Heitman
Author Joseph Heitman Molecular Genetics and Microbiology

Published In

Nat Rev Microbiol

DOI

10.1038/nrmicro1245

ISSN

1740-1526

Publication Date

October 2005

Volume

3

Issue

10

Start / End Page

753 / 764

Location

England

Related Subject Headings

  • Virulence
  • Signal Transduction
  • Sequence Analysis, DNA
  • Microbiology
  • Humans
  • Genome, Fungal
  • DNA Transposable Elements
  • Cryptococcus neoformans
  • Cryptococcosis
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Idnurm, A., Bahn, Y.-S., Nielsen, K., Lin, X., Fraser, J. A., & Heitman, J. (2005). Deciphering the model pathogenic fungus Cryptococcus neoformans. Nat Rev Microbiol, 3(10), 753–764. https://doi.org/10.1038/nrmicro1245
Idnurm, Alexander, Yong-Sun Bahn, Kirsten Nielsen, Xiaorong Lin, James A. Fraser, and Joseph Heitman. “Deciphering the model pathogenic fungus Cryptococcus neoformans.” Nat Rev Microbiol 3, no. 10 (October 2005): 753–64. https://doi.org/10.1038/nrmicro1245.
Idnurm A, Bahn Y-S, Nielsen K, Lin X, Fraser JA, Heitman J. Deciphering the model pathogenic fungus Cryptococcus neoformans. Nat Rev Microbiol. 2005 Oct;3(10):753–64.
Idnurm, Alexander, et al. “Deciphering the model pathogenic fungus Cryptococcus neoformans.” Nat Rev Microbiol, vol. 3, no. 10, Oct. 2005, pp. 753–64. Pubmed, doi:10.1038/nrmicro1245.
Idnurm A, Bahn Y-S, Nielsen K, Lin X, Fraser JA, Heitman J. Deciphering the model pathogenic fungus Cryptococcus neoformans. Nat Rev Microbiol. 2005 Oct;3(10):753–764.

Published In

Nat Rev Microbiol

DOI

10.1038/nrmicro1245

ISSN

1740-1526

Publication Date

October 2005

Volume

3

Issue

10

Start / End Page

753 / 764

Location

England

Related Subject Headings

  • Virulence
  • Signal Transduction
  • Sequence Analysis, DNA
  • Microbiology
  • Humans
  • Genome, Fungal
  • DNA Transposable Elements
  • Cryptococcus neoformans
  • Cryptococcosis
  • Animals