The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.
Publication
, Journal Article
Onyewu, C; Wormley, FL; Perfect, JR; Heitman, J
Published in: Infect Immun
December 2004
In Candida albicans, calcineurin is essential for virulence and survival during membrane perturbation by azoles. Crz1 is a proposed downstream target of calcineurin based on studies of Saccharomyces cerevisiae. However, the in vitro phenotypes of C. albicans crz1/crz1 and calcineurin mutants differ and Crz1 is not required for virulence.
Duke Scholars
Published In
Infect Immun
DOI
ISSN
0019-9567
Publication Date
December 2004
Volume
72
Issue
12
Start / End Page
7330 / 7333
Location
United States
Related Subject Headings
- Tacrolimus
- Microbiology
- Mice, Inbred ICR
- Mice
- Fluconazole
- Drug Resistance, Fungal
- Candida albicans
- Calcineurin
- Antifungal Agents
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Onyewu, C., Wormley, F. L., Perfect, J. R., & Heitman, J. (2004). The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans. Infect Immun, 72(12), 7330–7333. https://doi.org/10.1128/IAI.72.12.7330-7333.2004
Onyewu, Chiatogu, Floyd L. Wormley, John R. Perfect, and Joseph Heitman. “The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.” Infect Immun 72, no. 12 (December 2004): 7330–33. https://doi.org/10.1128/IAI.72.12.7330-7333.2004.
Onyewu C, Wormley FL, Perfect JR, Heitman J. The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans. Infect Immun. 2004 Dec;72(12):7330–3.
Onyewu, Chiatogu, et al. “The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.” Infect Immun, vol. 72, no. 12, Dec. 2004, pp. 7330–33. Pubmed, doi:10.1128/IAI.72.12.7330-7333.2004.
Onyewu C, Wormley FL, Perfect JR, Heitman J. The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans. Infect Immun. 2004 Dec;72(12):7330–7333.
Published In
Infect Immun
DOI
ISSN
0019-9567
Publication Date
December 2004
Volume
72
Issue
12
Start / End Page
7330 / 7333
Location
United States
Related Subject Headings
- Tacrolimus
- Microbiology
- Mice, Inbred ICR
- Mice
- Fluconazole
- Drug Resistance, Fungal
- Candida albicans
- Calcineurin
- Antifungal Agents
- Animals