Molecular dissection of lymphocyte signal transduction pathways.
Publication
, Journal Article
Perlmutter, RM
Published in: Pediatr Res
January 1993
The earliest biochemical changes in lymphocyte activation include the accumulation of phosphotyrosine-containing proteins. This accumulation, catalyzed by specific protein tyrosine kinases, is required for subsequent cell activation. Experimental manipulation of these protein tyrosine kinases results in improved or decreased transit through the activation sequence. Analysis of transgenic animals bearing altered kinase genes permits assembly of a model for signal transduction from the T-cell antigen receptor.
Duke Scholars
Published In
Pediatr Res
DOI
ISSN
0031-3998
Publication Date
January 1993
Volume
33
Issue
1 Suppl
Start / End Page
S9 / 13
Location
United States
Related Subject Headings
- T-Lymphocytes
- Signal Transduction
- Receptors, Antigen, T-Cell
- Protein-Tyrosine Kinases
- Pediatrics
- Mice
- Lymphocyte Activation
- Cell Line
- Animals
- 1117 Public Health and Health Services
Citation
APA
Chicago
ICMJE
MLA
NLM
Perlmutter, R. M. (1993). Molecular dissection of lymphocyte signal transduction pathways. Pediatr Res, 33(1 Suppl), S9-13. https://doi.org/10.1203/00006450-199305001-00041
Perlmutter, R. M. “Molecular dissection of lymphocyte signal transduction pathways.” Pediatr Res 33, no. 1 Suppl (January 1993): S9-13. https://doi.org/10.1203/00006450-199305001-00041.
Perlmutter RM. Molecular dissection of lymphocyte signal transduction pathways. Pediatr Res. 1993 Jan;33(1 Suppl):S9-13.
Perlmutter, R. M. “Molecular dissection of lymphocyte signal transduction pathways.” Pediatr Res, vol. 33, no. 1 Suppl, Jan. 1993, pp. S9-13. Pubmed, doi:10.1203/00006450-199305001-00041.
Perlmutter RM. Molecular dissection of lymphocyte signal transduction pathways. Pediatr Res. 1993 Jan;33(1 Suppl):S9-13.
Published In
Pediatr Res
DOI
ISSN
0031-3998
Publication Date
January 1993
Volume
33
Issue
1 Suppl
Start / End Page
S9 / 13
Location
United States
Related Subject Headings
- T-Lymphocytes
- Signal Transduction
- Receptors, Antigen, T-Cell
- Protein-Tyrosine Kinases
- Pediatrics
- Mice
- Lymphocyte Activation
- Cell Line
- Animals
- 1117 Public Health and Health Services