In-vitro modelling of the bactericidal activity of teicoplanin versus flucloxacillin as used in surgical prophylaxis, against Staphylococcus aureus.
Publication
, Journal Article
Steer, JA; Hill, GB; Robbins, MJ; Newton, JC; Wilson, AP
Published in: J Antimicrob Chemother
April 1997
The bactericidal activities of teicoplanin and flucloxacillin in a 50:50 mixture of human serum and Iso-sensitest broth were compared in an in-vitro pharmacokinetic model, at serum concentrations present during surgical prophylaxis. The bactericidal activity of teicoplanin with and without serum was also compared. Six strains of Staphylococcus aureus were tested. The bactericidal rate of teicoplanin in serum was significantly lower than the rate in broth alone. However, there was no significant difference in the bactericidal rates in serum of teicoplanin compared with flucloxacillin, an antibiotic which is commonly used as prophylaxis for certain surgical procedures.
Duke Scholars
Published In
J Antimicrob Chemother
DOI
ISSN
0305-7453
Publication Date
April 1997
Volume
39
Issue
4
Start / End Page
477 / 481
Location
England
Related Subject Headings
- Teicoplanin
- Staphylococcus aureus
- Staphylococcal Infections
- Penicillins
- Microbiology
- Microbial Sensitivity Tests
- Methicillin Resistance
- Humans
- Floxacillin
- Culture Media, Serum-Free
Citation
APA
Chicago
ICMJE
MLA
NLM
Steer, J. A., Hill, G. B., Robbins, M. J., Newton, J. C., & Wilson, A. P. (1997). In-vitro modelling of the bactericidal activity of teicoplanin versus flucloxacillin as used in surgical prophylaxis, against Staphylococcus aureus. J Antimicrob Chemother, 39(4), 477–481. https://doi.org/10.1093/jac/39.4.477
Steer, J. A., G. B. Hill, M. J. Robbins, J. C. Newton, and A. P. Wilson. “In-vitro modelling of the bactericidal activity of teicoplanin versus flucloxacillin as used in surgical prophylaxis, against Staphylococcus aureus.” J Antimicrob Chemother 39, no. 4 (April 1997): 477–81. https://doi.org/10.1093/jac/39.4.477.
Steer JA, Hill GB, Robbins MJ, Newton JC, Wilson AP. In-vitro modelling of the bactericidal activity of teicoplanin versus flucloxacillin as used in surgical prophylaxis, against Staphylococcus aureus. J Antimicrob Chemother. 1997 Apr;39(4):477–81.
Steer, J. A., et al. “In-vitro modelling of the bactericidal activity of teicoplanin versus flucloxacillin as used in surgical prophylaxis, against Staphylococcus aureus.” J Antimicrob Chemother, vol. 39, no. 4, Apr. 1997, pp. 477–81. Pubmed, doi:10.1093/jac/39.4.477.
Steer JA, Hill GB, Robbins MJ, Newton JC, Wilson AP. In-vitro modelling of the bactericidal activity of teicoplanin versus flucloxacillin as used in surgical prophylaxis, against Staphylococcus aureus. J Antimicrob Chemother. 1997 Apr;39(4):477–481.
Published In
J Antimicrob Chemother
DOI
ISSN
0305-7453
Publication Date
April 1997
Volume
39
Issue
4
Start / End Page
477 / 481
Location
England
Related Subject Headings
- Teicoplanin
- Staphylococcus aureus
- Staphylococcal Infections
- Penicillins
- Microbiology
- Microbial Sensitivity Tests
- Methicillin Resistance
- Humans
- Floxacillin
- Culture Media, Serum-Free