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JAPANESE MEDAKA LIVER TUMOR MODEL: REVIEW OF LITERATURE AND NEW FINDINGS.

Publication ,  Journal Article
Hinton, DE; Hampton, JA; McCuskey, PA
Published in: Water Chlorination: Environmental Impact and Health Effects
December 1, 1986

The Japanese medaka liver tumor model provides a rapid, in vivo screen for laboratory testing the carcinogenicity of aquatic pollutants. The high yield of tumors and associated brief induction period are strong arguments for using this model as an initial indicator in a multitiered testing program. Future studies to biologically characterize the medaka liver tumor(s) are needed. In addition, screening of a variety of compounds including proven mammalian carcinogens, promoters, cocarcinogens, weakly positive carcinogens, compounds considered negative, and compounds that may afford protection against carcinogenesis should be conducted. For other features of the medaka model and for a more complete discussion concerning fish as test organisms in carcinogenicity studies, the consensus report should be consulted.

Duke Scholars

Published In

Water Chlorination: Environmental Impact and Health Effects

Publication Date

December 1, 1986

Volume

5

Start / End Page

439 / 450
 

Citation

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Hinton, D. E., Hampton, J. A., & McCuskey, P. A. (1986). JAPANESE MEDAKA LIVER TUMOR MODEL: REVIEW OF LITERATURE AND NEW FINDINGS. Water Chlorination: Environmental Impact and Health Effects, 5, 439–450.
Hinton, D. E., J. A. Hampton, and P. A. McCuskey. “JAPANESE MEDAKA LIVER TUMOR MODEL: REVIEW OF LITERATURE AND NEW FINDINGS.Water Chlorination: Environmental Impact and Health Effects 5 (December 1, 1986): 439–50.
Hinton DE, Hampton JA, McCuskey PA. JAPANESE MEDAKA LIVER TUMOR MODEL: REVIEW OF LITERATURE AND NEW FINDINGS. Water Chlorination: Environmental Impact and Health Effects. 1986 Dec 1;5:439–50.
Hinton, D. E., et al. “JAPANESE MEDAKA LIVER TUMOR MODEL: REVIEW OF LITERATURE AND NEW FINDINGS.Water Chlorination: Environmental Impact and Health Effects, vol. 5, Dec. 1986, pp. 439–50.
Hinton DE, Hampton JA, McCuskey PA. JAPANESE MEDAKA LIVER TUMOR MODEL: REVIEW OF LITERATURE AND NEW FINDINGS. Water Chlorination: Environmental Impact and Health Effects. 1986 Dec 1;5:439–450.

Published In

Water Chlorination: Environmental Impact and Health Effects

Publication Date

December 1, 1986

Volume

5

Start / End Page

439 / 450