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Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.

Publication ,  Journal Article
Streeper, RS; Grueter, CA; Salomonis, N; Cases, S; Levin, MC; Koliwad, SK; Zhou, P; Hirschey, MD; Verdin, E; Farese, RV
Published in: Aging (Albany NY)
January 2012

Calorie restriction results in leanness, which is linked to metabolic conditions that favor longevity. We show here that deficiency of the triglyceride synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which promotes leanness, also extends longevity without limiting food intake. Female DGAT1-deficient mice were protected from age-related increases in body fat, tissue triglycerides, and inflammation in white adipose tissue. This protection was accompanied by increased mean and maximal life spans of ~25% and ~10%, respectively. Middle-agedDgat1-/- mice exhibited several features associated with longevity, including decreased levels of circulating insulin growth factor 1 (IGF1) and reduced fecundity. Thus, deletion of DGAT1 in mice provides a model of leanness and extended lifespan that is independent of calorie restriction.

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Published In

Aging (Albany NY)

DOI

EISSN

1945-4589

Publication Date

January 2012

Volume

4

Issue

1

Start / End Page

13 / 27

Location

United States

Related Subject Headings

  • Thinness
  • Mice, Knockout
  • Mice
  • Longevity
  • Litter Size
  • Genotype
  • Gene Expression Regulation
  • Gene Expression Profiling
  • Fertility
  • Female
 

Citation

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Streeper, R. S., Grueter, C. A., Salomonis, N., Cases, S., Levin, M. C., Koliwad, S. K., … Farese, R. V. (2012). Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging (Albany NY), 4(1), 13–27. https://doi.org/10.18632/aging.100424
Streeper, Ryan S., Carrie A. Grueter, Nathan Salomonis, Sylvaine Cases, Malin C. Levin, Suneil K. Koliwad, Ping Zhou, Mattew D. Hirschey, Eric Verdin, and Robert V. Farese. “Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.Aging (Albany NY) 4, no. 1 (January 2012): 13–27. https://doi.org/10.18632/aging.100424.
Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, et al. Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging (Albany NY). 2012 Jan;4(1):13–27.
Streeper, Ryan S., et al. “Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.Aging (Albany NY), vol. 4, no. 1, Jan. 2012, pp. 13–27. Pubmed, doi:10.18632/aging.100424.
Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, Zhou P, Hirschey MD, Verdin E, Farese RV. Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging (Albany NY). 2012 Jan;4(1):13–27.

Published In

Aging (Albany NY)

DOI

EISSN

1945-4589

Publication Date

January 2012

Volume

4

Issue

1

Start / End Page

13 / 27

Location

United States

Related Subject Headings

  • Thinness
  • Mice, Knockout
  • Mice
  • Longevity
  • Litter Size
  • Genotype
  • Gene Expression Regulation
  • Gene Expression Profiling
  • Fertility
  • Female