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Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation.

Publication ,  Journal Article
Church, FC; Hoffman, MR
Published in: Trends Cardiovasc Med
1994

α-Thrombin is a trypsinlike serine proteinase involved in blood coagulation and wound-healing processes, which interacts with many different macromolecular substances. Heparin cofactor II is a serpin (serine proteinase inhibitor) superfamily member that specifically inhibits thrombin but no other proteinase in blood coagulation. Both heparin cofactor II and thrombin interact with highly negatively charged glycosaminoglycans like heparin and dermatan sulfate, and they both are leukocyte chemoattractants. The focus of this brief review is structure-function characteristics of heparin cofactor II and thrombin and their physiologic participation in uniting hemostatic and inflammatory processes.

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Published In

Trends Cardiovasc Med

DOI

ISSN

1050-1738

Publication Date

1994

Volume

4

Issue

3

Start / End Page

140 / 146

Location

United States

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

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Church, F. C., & Hoffman, M. R. (1994). Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation. Trends Cardiovasc Med, 4(3), 140–146. https://doi.org/10.1016/1050-1738(94)90066-3
Church, F. C., and M. R. Hoffman. “Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation.Trends Cardiovasc Med 4, no. 3 (1994): 140–46. https://doi.org/10.1016/1050-1738(94)90066-3.
Church FC, Hoffman MR. Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation. Trends Cardiovasc Med. 1994;4(3):140–6.
Church, F. C., and M. R. Hoffman. “Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation.Trends Cardiovasc Med, vol. 4, no. 3, 1994, pp. 140–46. Pubmed, doi:10.1016/1050-1738(94)90066-3.
Church FC, Hoffman MR. Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation. Trends Cardiovasc Med. 1994;4(3):140–146.
Journal cover image

Published In

Trends Cardiovasc Med

DOI

ISSN

1050-1738

Publication Date

1994

Volume

4

Issue

3

Start / End Page

140 / 146

Location

United States

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology