Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation.
Publication
, Journal Article
Church, FC; Hoffman, MR
Published in: Trends Cardiovasc Med
1994
α-Thrombin is a trypsinlike serine proteinase involved in blood coagulation and wound-healing processes, which interacts with many different macromolecular substances. Heparin cofactor II is a serpin (serine proteinase inhibitor) superfamily member that specifically inhibits thrombin but no other proteinase in blood coagulation. Both heparin cofactor II and thrombin interact with highly negatively charged glycosaminoglycans like heparin and dermatan sulfate, and they both are leukocyte chemoattractants. The focus of this brief review is structure-function characteristics of heparin cofactor II and thrombin and their physiologic participation in uniting hemostatic and inflammatory processes.
Duke Scholars
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Published In
Trends Cardiovasc Med
DOI
ISSN
1050-1738
Publication Date
1994
Volume
4
Issue
3
Start / End Page
140 / 146
Location
United States
Related Subject Headings
- Cardiovascular System & Hematology
- 3201 Cardiovascular medicine and haematology
- 1102 Cardiorespiratory Medicine and Haematology
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Church, F. C., & Hoffman, M. R. (1994). Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation. Trends Cardiovasc Med, 4(3), 140–146. https://doi.org/10.1016/1050-1738(94)90066-3
Church, F. C., and M. R. Hoffman. “Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation.” Trends Cardiovasc Med 4, no. 3 (1994): 140–46. https://doi.org/10.1016/1050-1738(94)90066-3.
Church FC, Hoffman MR. Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation. Trends Cardiovasc Med. 1994;4(3):140–6.
Church, F. C., and M. R. Hoffman. “Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation.” Trends Cardiovasc Med, vol. 4, no. 3, 1994, pp. 140–46. Pubmed, doi:10.1016/1050-1738(94)90066-3.
Church FC, Hoffman MR. Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation. Trends Cardiovasc Med. 1994;4(3):140–146.
Published In
Trends Cardiovasc Med
DOI
ISSN
1050-1738
Publication Date
1994
Volume
4
Issue
3
Start / End Page
140 / 146
Location
United States
Related Subject Headings
- Cardiovascular System & Hematology
- 3201 Cardiovascular medicine and haematology
- 1102 Cardiorespiratory Medicine and Haematology