Sox2 is required for development of taste bud sensory cells.
Publication
, Journal Article
Okubo, T; Pevny, LH; Hogan, BLM
Published in: Genes Dev
October 1, 2006
Sox2 is expressed in basal epithelial cells of the tongue, with high levels in taste bud placodes, fungiform papillae, and mature taste cells, and low levels in filiform papillae. High Sox2 expression appears to lie downstream from canonical Wnt signaling. In hypomorphic Sox2(EGFP/LP) embryos, placodes form but no mature taste buds develop. In contrast, transgenic overexpression of Sox2 in the basal cells inhibits differentiation of filiform keratinocytes. Together, our loss-of-function and gain-of-function studies suggest that Sox2 functions in a dose-dependent manner to regulate the differentiation of endodermal progenitor cells of the tongue into taste bud sensory cells versus keratinocytes.
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Published In
Genes Dev
DOI
ISSN
0890-9369
Publication Date
October 1, 2006
Volume
20
Issue
19
Start / End Page
2654 / 2659
Location
United States
Related Subject Headings
- Wnt Proteins
- Trans-Activators
- Tongue
- Taste Buds
- SOXB1 Transcription Factors
- Phenotype
- Models, Biological
- Mice, Transgenic
- Mice, Mutant Strains
- Mice
Citation
APA
Chicago
ICMJE
MLA
NLM
Okubo, T., Pevny, L. H., & Hogan, B. L. M. (2006). Sox2 is required for development of taste bud sensory cells. Genes Dev, 20(19), 2654–2659. https://doi.org/10.1101/gad.1457106
Okubo, Tadashi, Larysa H. Pevny, and Brigid L. M. Hogan. “Sox2 is required for development of taste bud sensory cells.” Genes Dev 20, no. 19 (October 1, 2006): 2654–59. https://doi.org/10.1101/gad.1457106.
Okubo T, Pevny LH, Hogan BLM. Sox2 is required for development of taste bud sensory cells. Genes Dev. 2006 Oct 1;20(19):2654–9.
Okubo, Tadashi, et al. “Sox2 is required for development of taste bud sensory cells.” Genes Dev, vol. 20, no. 19, Oct. 2006, pp. 2654–59. Pubmed, doi:10.1101/gad.1457106.
Okubo T, Pevny LH, Hogan BLM. Sox2 is required for development of taste bud sensory cells. Genes Dev. 2006 Oct 1;20(19):2654–2659.
Published In
Genes Dev
DOI
ISSN
0890-9369
Publication Date
October 1, 2006
Volume
20
Issue
19
Start / End Page
2654 / 2659
Location
United States
Related Subject Headings
- Wnt Proteins
- Trans-Activators
- Tongue
- Taste Buds
- SOXB1 Transcription Factors
- Phenotype
- Models, Biological
- Mice, Transgenic
- Mice, Mutant Strains
- Mice