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An essential role of Bmp4 in the atrioventricular septation of the mouse heart.

Publication ,  Journal Article
Jiao, K; Kulessa, H; Tompkins, K; Zhou, Y; Batts, L; Baldwin, HS; Hogan, BLM
Published in: Genes Dev
October 1, 2003

Proper septation and valvulogenesis during cardiogenesis depend on interactions between the myocardium and the endocardium. By combining use of a hypomorphic Bone morphogenetic protein 4 (Bmp4) allele with conditional gene inactivation, we here identify Bmp4 as a signal from the myocardium directly mediating atrioventricular septation. Defects in this process cause one of the most common human congenital heart abnormalities, atrioventricular canal defect (AVCD). The spectrum of defects obtained through altering Bmp4 expression in the myocardium recapitulates the range of AVCDs diagnosed in patients, thus providing a useful genetic model with AVCD as the primary defect.

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Published In

Genes Dev

DOI

ISSN

0890-9369

Publication Date

October 1, 2003

Volume

17

Issue

19

Start / End Page

2362 / 2367

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta2
  • Transforming Growth Factor beta
  • Signal Transduction
  • Myocytes, Cardiac
  • Mice, Transgenic
  • Mice, Mutant Strains
  • Mice
  • Heart Defects, Congenital
  • Heart
  • Gene Expression Regulation, Developmental
 

Citation

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Jiao, K., Kulessa, H., Tompkins, K., Zhou, Y., Batts, L., Baldwin, H. S., & Hogan, B. L. M. (2003). An essential role of Bmp4 in the atrioventricular septation of the mouse heart. Genes Dev, 17(19), 2362–2367. https://doi.org/10.1101/gad.1124803
Jiao, Kai, Holger Kulessa, Kevin Tompkins, Yingna Zhou, Lorene Batts, H Scott Baldwin, and Brigid L. M. Hogan. “An essential role of Bmp4 in the atrioventricular septation of the mouse heart.Genes Dev 17, no. 19 (October 1, 2003): 2362–67. https://doi.org/10.1101/gad.1124803.
Jiao K, Kulessa H, Tompkins K, Zhou Y, Batts L, Baldwin HS, et al. An essential role of Bmp4 in the atrioventricular septation of the mouse heart. Genes Dev. 2003 Oct 1;17(19):2362–7.
Jiao, Kai, et al. “An essential role of Bmp4 in the atrioventricular septation of the mouse heart.Genes Dev, vol. 17, no. 19, Oct. 2003, pp. 2362–67. Pubmed, doi:10.1101/gad.1124803.
Jiao K, Kulessa H, Tompkins K, Zhou Y, Batts L, Baldwin HS, Hogan BLM. An essential role of Bmp4 in the atrioventricular septation of the mouse heart. Genes Dev. 2003 Oct 1;17(19):2362–2367.

Published In

Genes Dev

DOI

ISSN

0890-9369

Publication Date

October 1, 2003

Volume

17

Issue

19

Start / End Page

2362 / 2367

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta2
  • Transforming Growth Factor beta
  • Signal Transduction
  • Myocytes, Cardiac
  • Mice, Transgenic
  • Mice, Mutant Strains
  • Mice
  • Heart Defects, Congenital
  • Heart
  • Gene Expression Regulation, Developmental