Scholars@Duke publication: Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men.

Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men.

Publication , Journal Article

Nishimura, H; Yerkes, E; Hohenfellner, K; Miyazaki, Y; Ma, J; Hunley, TE; Yoshida, H; Ichiki, T; Threadgill, D; Phillips, JA; Hogan, BM ...

Published in: Mol Cell

January 1999

Published version (DOI) Link to item

Angiotensin type 2 receptor gene null mutant mice display congenital anomalies of the kidney and urinary tract (CAKUT). Various features of mouse CAKUT impressively mimic human CAKUT. Studies of the human type 2 receptor (AGTR2) gene in two independent cohorts found that a significant association exists between CAKUT and a nucleotide transition within the lariat branchpoint motif of intron 1, which perturbs AGTR2 mRNA splicing efficiency. AGTR2, therefore, has a significant ontogenic role for the kidney and urinary tract system. Studies revealed that the establishment of CAKUT is preceded by delayed apoptosis of undifferentiated mesenchymal cells surrounding the urinary tract during key ontogenic events, from the ureteral budding to the expansive growth of the kidney and ureter.

Duke Scholars

Author Brigid L. M. Hogan Cell Biology

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Published In

Mol Cell

DOI

10.1016/s1097-2765(00)80169-0

ISSN

1097-2765

Publication Date

January 1999

Volume

Issue

Start / End Page

1 / 10

Location

United States

Related Subject Headings

Urologic Diseases
Urinary Tract
Sequence Analysis, DNA
Receptors, Angiotensin
RNA, Messenger
RNA Splicing
Polymorphism, Restriction Fragment Length
Phenotype
Pedigree
Mutation

Citation

APA

Chicago

ICMJE

MLA

NLM

Nishimura, H., Yerkes, E., Hohenfellner, K., Miyazaki, Y., Ma, J., Hunley, T. E., … Ichikawa, I. (1999). Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell, 3(1), 1–10. https://doi.org/10.1016/s1097-2765(00)80169-0

Nishimura, H., E. Yerkes, K. Hohenfellner, Y. Miyazaki, J. Ma, T. E. Hunley, H. Yoshida, et al. “Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men.” Mol Cell 3, no. 1 (January 1999): 1–10. https://doi.org/10.1016/s1097-2765(00)80169-0.

Nishimura H, Yerkes E, Hohenfellner K, Miyazaki Y, Ma J, Hunley TE, et al. Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell. 1999 Jan;3(1):1–10.

Nishimura, H., et al. “Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men.” Mol Cell, vol. 3, no. 1, Jan. 1999, pp. 1–10. Pubmed, doi:10.1016/s1097-2765(00)80169-0.

Nishimura H, Yerkes E, Hohenfellner K, Miyazaki Y, Ma J, Hunley TE, Yoshida H, Ichiki T, Threadgill D, Phillips JA, Hogan BM, Fogo A, Brock JW, Inagami T, Ichikawa I. Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell. 1999 Jan;3(1):1–10.

Published In

Mol Cell

DOI

10.1016/s1097-2765(00)80169-0

ISSN

1097-2765

Publication Date

January 1999

Volume

Issue

Start / End Page

1 / 10

Location

United States

Related Subject Headings

Urologic Diseases
Urinary Tract
Sequence Analysis, DNA
Receptors, Angiotensin
RNA, Messenger
RNA Splicing
Polymorphism, Restriction Fragment Length
Phenotype
Pedigree
Mutation