New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C.
Publication
, Journal Article
Kashiwada, Y; Huang, L; Ballas, LM; Jiang, JB; Janzen, WP; Lee, KH
Published in: J Med Chem
January 7, 1994
We have previously shown that some ellagitannins are potent inhibitors of protein kinase C (PKC). On the basis of this finding, several series of hexahydroxybiphenyl derivatives of ellagic acid were synthesized as simple analogs of these ellagitannins and were evaluated for their inhibitory effect against PKC. Compounds 23 and 26 were found to be potent inhibitors of PKC, while hexakis-(benzyloxy)biphenyl derivatives exhibited weak anti-PKC activity.
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Published In
J Med Chem
DOI
ISSN
0022-2623
Publication Date
January 7, 1994
Volume
37
Issue
1
Start / End Page
195 / 200
Location
United States
Related Subject Headings
- Structure-Activity Relationship
- Recombinant Proteins
- Protein Kinase C
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Humans
- Ellagic Acid
- Dibenzoxepins
- Biphenyl Compounds
- 3405 Organic chemistry
Citation
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Kashiwada, Y., Huang, L., Ballas, L. M., Jiang, J. B., Janzen, W. P., & Lee, K. H. (1994). New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem, 37(1), 195–200. https://doi.org/10.1021/jm00027a025
Kashiwada, Y., L. Huang, L. M. Ballas, J. B. Jiang, W. P. Janzen, and K. H. Lee. “New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C.” J Med Chem 37, no. 1 (January 7, 1994): 195–200. https://doi.org/10.1021/jm00027a025.
Kashiwada Y, Huang L, Ballas LM, Jiang JB, Janzen WP, Lee KH. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem. 1994 Jan 7;37(1):195–200.
Kashiwada, Y., et al. “New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C.” J Med Chem, vol. 37, no. 1, Jan. 1994, pp. 195–200. Pubmed, doi:10.1021/jm00027a025.
Kashiwada Y, Huang L, Ballas LM, Jiang JB, Janzen WP, Lee KH. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem. 1994 Jan 7;37(1):195–200.
Published In
J Med Chem
DOI
ISSN
0022-2623
Publication Date
January 7, 1994
Volume
37
Issue
1
Start / End Page
195 / 200
Location
United States
Related Subject Headings
- Structure-Activity Relationship
- Recombinant Proteins
- Protein Kinase C
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Humans
- Ellagic Acid
- Dibenzoxepins
- Biphenyl Compounds
- 3405 Organic chemistry