The development and function of memory regulatory T cells after acute viral infections.
Natural CD4+CD25+Foxp3+ regulatory T cells (Tregs) are critical for the control of immune responses to pathogens. However, most studies have focused on chronic infections, in which pathogen-specific Tregs contribute to pathogen persistence and, in some cases, concomitant immunity. How Tregs behave and function following acute infections remains largely unknown. In this article, we show that pathogen-specific Tregs can be activated and expand upon acute viral infections in vivo. The activated Tregs then contract to form a memory pool after resolution of the infection. These memory Tregs expand rapidly upon a secondary challenge, secrete large amounts of IL-10, and suppress excessive immunopathological conditions elicited by recall expansion of non-Tregs via an IL-10-dependent mechanism. Our work reveals a memory Treg population that develops after acute viral infections and may help in the design of effective strategies to circumvent excessive immunopathological effects.
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Related Subject Headings
- Vaccinia virus
- T-Lymphocytes, Regulatory
- Mice, Transgenic
- Mice, Inbred C57BL
- Mice, Inbred BALB C
- Mice
- Lymphocyte Activation
- Interleukin-10
- Influenza A virus
- Immunology
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Vaccinia virus
- T-Lymphocytes, Regulatory
- Mice, Transgenic
- Mice, Inbred C57BL
- Mice, Inbred BALB C
- Mice
- Lymphocyte Activation
- Interleukin-10
- Influenza A virus
- Immunology