Skip to main content

Non-linearities in the blood-oxygenation-level dependent (BOLD) response measured by functional magnetic resonance imaging (fMRI).

Publication ,  Journal Article
Huettel, SA
Published in: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
January 2004

A central question in the analysis of functional magnetic resonance imaging (IMRI) data is whether the measured fMRI signal summates in a linear fashion over repeated inputs. Most fMRI studies collect images sensitive to blood-oxygenation-level dependent (BOLD) contrast, which measures the local amount of deoxygenated hemoglobin (dHb). When neurons are active, more oxygenated hemoglobin is supplied than is needed for their metabolic demands, resulting in a decrease in dHb and an increase in MR signal. For analysis of fMRI data, researchers must therefore create experimental hypotheses of the measurable BOLD response based upon the predicted neuronal activity. An influential early model of the fMRI BOLD response assumes that BOLD activity is a linear transformation of neuronal input, representing the filtering effects of the vascular system. Recent studies have called this interpretation into question, due to observed differences in the pattern of linearity across brain regions that serve distinct functions.

Duke Scholars

Published In

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

DOI

ISSN

1557-170X

Publication Date

January 2004

Volume

2004

Start / End Page

4413 / 4416
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Huettel, S. A. (2004). Non-linearities in the blood-oxygenation-level dependent (BOLD) response measured by functional magnetic resonance imaging (fMRI). Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2004, 4413–4416. https://doi.org/10.1109/iembs.2004.1404227
Huettel, S. A. “Non-linearities in the blood-oxygenation-level dependent (BOLD) response measured by functional magnetic resonance imaging (fMRI).Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2004 (January 2004): 4413–16. https://doi.org/10.1109/iembs.2004.1404227.
Huettel SA. Non-linearities in the blood-oxygenation-level dependent (BOLD) response measured by functional magnetic resonance imaging (fMRI). Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual Conference. 2004 Jan;2004:4413–6.
Huettel, S. A. “Non-linearities in the blood-oxygenation-level dependent (BOLD) response measured by functional magnetic resonance imaging (fMRI).Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2004, Jan. 2004, pp. 4413–16. Epmc, doi:10.1109/iembs.2004.1404227.
Huettel SA. Non-linearities in the blood-oxygenation-level dependent (BOLD) response measured by functional magnetic resonance imaging (fMRI). Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual Conference. 2004 Jan;2004:4413–4416.

Published In

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

DOI

ISSN

1557-170X

Publication Date

January 2004

Volume

2004

Start / End Page

4413 / 4416