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Angiogenesis inhibition in the treatment of colorectal cancer Part 3 of a 3-part series: targeting VEGF--current and future research directions.

Publication ,  Journal Article
Goldberg, RM; Hurwitz, HI; Fuchs, CS
Published in: Clin Adv Hematol Oncol
December 2005

Treatment options for advanced colorectal have improved substantially in recent years as a number of agents have been developed that have different targets and mechanisms of action. Significant improvements in outcomes have been observed by combining multiple chemotherapeutic agents instead of the single-agent approach. Some debate still remains regarding which combination is most effective and in what order regimens should be given. In addition to cytotoxic chemotherapy drugs, targeted biologic agents have been developed to inhibit tumor angiogenesis, which may hamper the viability of the tumor. There may also be a synergistic effect between antiangiogenic agents and chemotherapy. Regulation of tumor angiogenesis may actually improve blood flow throughout the tumor, which could enhance delivery of chemotherapy through the circulation. One antiangiogenic agent currently approved for the treatment of advanced colorectal cancer is bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor, a ligand known to be important for angiogenesis. The other currently approved biologic agent, cetuximab, targets the epidermal growth factor receptor. The combination of bevacizumab plus cetuximab has a biologic rationale. Randomized trials incorporating combination chemotherapy regimens plus both bevacizumab and cetuximab are currently underway, as are preliminary studies withnovel angiogenesis inhibitors.

Duke Scholars

Published In

Clin Adv Hematol Oncol

ISSN

1543-0790

Publication Date

December 2005

Volume

3

Issue

12

Start / End Page

1 / 10

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Oncology & Carcinogenesis
  • Humans
  • ErbB Receptors
  • Colorectal Neoplasms
  • Cetuximab
  • Bevacizumab
  • Antibodies, Monoclonal, Humanized
  • Antibodies, Monoclonal
  • Angiogenesis Inhibitors
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Goldberg, Richard M., Herbert I. Hurwitz, and Charles S. Fuchs. “Angiogenesis inhibition in the treatment of colorectal cancer Part 3 of a 3-part series: targeting VEGF--current and future research directions.Clin Adv Hematol Oncol 3, no. 12 (December 2005): 1–10.
Goldberg, Richard M., et al. “Angiogenesis inhibition in the treatment of colorectal cancer Part 3 of a 3-part series: targeting VEGF--current and future research directions.Clin Adv Hematol Oncol, vol. 3, no. 12, Dec. 2005, pp. 1–10.

Published In

Clin Adv Hematol Oncol

ISSN

1543-0790

Publication Date

December 2005

Volume

3

Issue

12

Start / End Page

1 / 10

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Oncology & Carcinogenesis
  • Humans
  • ErbB Receptors
  • Colorectal Neoplasms
  • Cetuximab
  • Bevacizumab
  • Antibodies, Monoclonal, Humanized
  • Antibodies, Monoclonal
  • Angiogenesis Inhibitors