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Real-time spectral domain Doppler optical coherence tomography and investigation of human retinal vessel autoregulation.

Publication ,  Journal Article
Bower, BA; Zhao, M; Zawadzki, RJ; Izatt, JA
Published in: Journal of biomedical optics
July 2007

Investigation of the autoregulatory mechanism of human retinal perfusion is conducted with a real-time spectral domain Doppler optical coherence tomography (SDOCT) system. Volumetric, time-sequential, and Doppler flow imaging are performed in the inferior arcade region on normal healthy subjects breathing normal room air and 100% oxygen. The real-time Doppler SDOCT system displays fully processed, high-resolution [512 (axial) x 1000 (lateral) pixels] B scans at 17 frames/sec in volumetric and time-sequential imaging modes, and also displays fully processed overlaid color Doppler flow images comprising 512 (axial) x 500 (lateral) pixels at 6 frames/sec. Data acquired following 5 min of 100% oxygen inhalation is compared with that acquired 5 min postinhalation for four healthy subjects. The average vessel constriction across the population is -16+/-26% after oxygen inhalation with a dilation of 36+/-54% after a return to room air. The flow decreases by -6+/-20% in response to oxygen and in turn increases by 21+/-28% as flow returns to normal in response to room air. These trends are in agreement with those previously reported using laser Doppler velocimetry to study retinal vessel autoregulation. Doppler flow repeatability data are presented to address the high standard deviations in the measurements.

Duke Scholars

Published In

Journal of biomedical optics

DOI

EISSN

1560-2281

ISSN

1083-3668

Publication Date

July 2007

Volume

12

Issue

4

Start / End Page

041214

Related Subject Headings

  • Tomography, Optical Coherence
  • Sensitivity and Specificity
  • Retinoscopy
  • Retinal Vessels
  • Reproducibility of Results
  • Oximetry
  • Optics
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bower, B. A., Zhao, M., Zawadzki, R. J., & Izatt, J. A. (2007). Real-time spectral domain Doppler optical coherence tomography and investigation of human retinal vessel autoregulation. Journal of Biomedical Optics, 12(4), 041214. https://doi.org/10.1117/1.2772877
Bower, Bradley A., Mingtao Zhao, Robert J. Zawadzki, and Joseph A. Izatt. “Real-time spectral domain Doppler optical coherence tomography and investigation of human retinal vessel autoregulation.Journal of Biomedical Optics 12, no. 4 (July 2007): 041214. https://doi.org/10.1117/1.2772877.
Bower BA, Zhao M, Zawadzki RJ, Izatt JA. Real-time spectral domain Doppler optical coherence tomography and investigation of human retinal vessel autoregulation. Journal of biomedical optics. 2007 Jul;12(4):041214.
Bower, Bradley A., et al. “Real-time spectral domain Doppler optical coherence tomography and investigation of human retinal vessel autoregulation.Journal of Biomedical Optics, vol. 12, no. 4, July 2007, p. 041214. Epmc, doi:10.1117/1.2772877.
Bower BA, Zhao M, Zawadzki RJ, Izatt JA. Real-time spectral domain Doppler optical coherence tomography and investigation of human retinal vessel autoregulation. Journal of biomedical optics. 2007 Jul;12(4):041214.

Published In

Journal of biomedical optics

DOI

EISSN

1560-2281

ISSN

1083-3668

Publication Date

July 2007

Volume

12

Issue

4

Start / End Page

041214

Related Subject Headings

  • Tomography, Optical Coherence
  • Sensitivity and Specificity
  • Retinoscopy
  • Retinal Vessels
  • Reproducibility of Results
  • Oximetry
  • Optics
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
  • Humans