Toll-like receptor 7 mediates pruritus.
Publication
, Journal Article
Liu, T; Xu, Z-Z; Park, C-K; Berta, T; Ji, R-R
Published in: Nat Neurosci
December 2010
Toll-like receptors are typically expressed in immune cells to regulate innate immunity. We found that functional Toll-like receptor 7 (TLR7) was expressed in C-fiber primary sensory neurons and was important for inducing itch (pruritus), but was not necessary for eliciting mechanical, thermal, inflammatory and neuropathic pain in mice. Our results indicate that TLR7 mediates itching and is a potential therapeutic target for anti-itch treatment in skin disease conditions.
Duke Scholars
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Published In
Nat Neurosci
DOI
EISSN
1546-1726
Publication Date
December 2010
Volume
13
Issue
12
Start / End Page
1460 / 1462
Location
United States
Related Subject Headings
- Toll-Like Receptor 7
- Pruritus
- Pain Measurement
- Neurology & Neurosurgery
- Nerve Fibers, Unmyelinated
- Mice, Transgenic
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
- Membrane Glycoproteins
Citation
APA
Chicago
ICMJE
MLA
NLM
Liu, T., Xu, Z.-Z., Park, C.-K., Berta, T., & Ji, R.-R. (2010). Toll-like receptor 7 mediates pruritus. Nat Neurosci, 13(12), 1460–1462. https://doi.org/10.1038/nn.2683
Liu, Tong, Zhen-Zhong Xu, Chul-Kyu Park, Temugin Berta, and Ru-Rong Ji. “Toll-like receptor 7 mediates pruritus.” Nat Neurosci 13, no. 12 (December 2010): 1460–62. https://doi.org/10.1038/nn.2683.
Liu T, Xu Z-Z, Park C-K, Berta T, Ji R-R. Toll-like receptor 7 mediates pruritus. Nat Neurosci. 2010 Dec;13(12):1460–2.
Liu, Tong, et al. “Toll-like receptor 7 mediates pruritus.” Nat Neurosci, vol. 13, no. 12, Dec. 2010, pp. 1460–62. Pubmed, doi:10.1038/nn.2683.
Liu T, Xu Z-Z, Park C-K, Berta T, Ji R-R. Toll-like receptor 7 mediates pruritus. Nat Neurosci. 2010 Dec;13(12):1460–1462.
Published In
Nat Neurosci
DOI
EISSN
1546-1726
Publication Date
December 2010
Volume
13
Issue
12
Start / End Page
1460 / 1462
Location
United States
Related Subject Headings
- Toll-Like Receptor 7
- Pruritus
- Pain Measurement
- Neurology & Neurosurgery
- Nerve Fibers, Unmyelinated
- Mice, Transgenic
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
- Membrane Glycoproteins