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Should selective serotonin reuptake inhibitors be prescribed to all patients with ischemic heart disease?

Publication ,  Journal Article
Jiang, W; Krishnan, RR
Published in: Curr Psychiatry Rep
June 2004

Recent studies have uncovered more and more evidence demonstrating the adverse relationship between depression and ischemic heart disease. One of the most significant mechanisms that may explain the adverse relationship is the increased platelet activity, otherwise known as aggregation, observed to occur in patients with depression or ischemic heart disease. Platelet activity is further elevated in patients with depression and ischemic heart disease. Selective serotonin reuptake inhibitors are antidepressants and also act like platelet inhibitors. The results of large-scale clinical trials suggest that the use of selective serotonin reuptake inhibitors may reduce cardiac events in post-myocardial infarction patients or in those with unstable angina that may be related to the effects of selective serotonin reuptake inhibitors on platelet aggregation.

Duke Scholars

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Published In

Curr Psychiatry Rep

DOI

ISSN

1523-3812

Publication Date

June 2004

Volume

6

Issue

3

Start / End Page

202 / 209

Location

United States

Related Subject Headings

  • Selective Serotonin Reuptake Inhibitors
  • Psychiatry
  • Platelet Aggregation
  • Myocardial Ischemia
  • Myocardial Infarction
  • Humans
  • Drug Prescriptions
  • Depression
  • Clinical Trials as Topic
  • Antidepressive Agents, Second-Generation
 

Citation

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Jiang, W., & Krishnan, R. R. (2004). Should selective serotonin reuptake inhibitors be prescribed to all patients with ischemic heart disease? Curr Psychiatry Rep, 6(3), 202–209. https://doi.org/10.1007/s11920-004-0065-1
Jiang, Wei, and Ranga R. Krishnan. “Should selective serotonin reuptake inhibitors be prescribed to all patients with ischemic heart disease?Curr Psychiatry Rep 6, no. 3 (June 2004): 202–9. https://doi.org/10.1007/s11920-004-0065-1.
Jiang, Wei, and Ranga R. Krishnan. “Should selective serotonin reuptake inhibitors be prescribed to all patients with ischemic heart disease?Curr Psychiatry Rep, vol. 6, no. 3, June 2004, pp. 202–09. Pubmed, doi:10.1007/s11920-004-0065-1.
Journal cover image

Published In

Curr Psychiatry Rep

DOI

ISSN

1523-3812

Publication Date

June 2004

Volume

6

Issue

3

Start / End Page

202 / 209

Location

United States

Related Subject Headings

  • Selective Serotonin Reuptake Inhibitors
  • Psychiatry
  • Platelet Aggregation
  • Myocardial Ischemia
  • Myocardial Infarction
  • Humans
  • Drug Prescriptions
  • Depression
  • Clinical Trials as Topic
  • Antidepressive Agents, Second-Generation