Skip to main content

Sample size and power calculation for molecular biology studies.

Publication ,  Journal Article
Jung, S-H
Published in: Methods Mol Biol
2010

Sample size calculation is a critical procedure when designing a new biological study. In this chapter, we consider molecular biology studies generating huge dimensional data. Microarray studies are typical examples, so that we state this chapter in terms of gene microarray data, but the discussed methods can be used for design and analysis of any molecular biology studies involving high-dimensional data. In this chapter, we discuss sample size calculation methods for molecular biology studies when the discovery of prognostic molecular markers is performed by accurately controlling false discovery rate (FDR) or family-wise error rate (FWER) in the final data analysis. We limit our discussion to the two-sample case.

Duke Scholars

Published In

Methods Mol Biol

DOI

EISSN

1940-6029

Publication Date

2010

Volume

620

Start / End Page

203 / 218

Location

United States

Related Subject Headings

  • Sample Size
  • Oligonucleotide Array Sequence Analysis
  • Molecular Biology
  • Humans
  • Female
  • Developmental Biology
  • Breast Neoplasms
  • Biostatistics
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jung, S.-H. (2010). Sample size and power calculation for molecular biology studies. Methods Mol Biol, 620, 203–218. https://doi.org/10.1007/978-1-60761-580-4_5
Jung, Sin-Ho. “Sample size and power calculation for molecular biology studies.Methods Mol Biol 620 (2010): 203–18. https://doi.org/10.1007/978-1-60761-580-4_5.
Jung S-H. Sample size and power calculation for molecular biology studies. Methods Mol Biol. 2010;620:203–18.
Jung, Sin-Ho. “Sample size and power calculation for molecular biology studies.Methods Mol Biol, vol. 620, 2010, pp. 203–18. Pubmed, doi:10.1007/978-1-60761-580-4_5.
Jung S-H. Sample size and power calculation for molecular biology studies. Methods Mol Biol. 2010;620:203–218.

Published In

Methods Mol Biol

DOI

EISSN

1940-6029

Publication Date

2010

Volume

620

Start / End Page

203 / 218

Location

United States

Related Subject Headings

  • Sample Size
  • Oligonucleotide Array Sequence Analysis
  • Molecular Biology
  • Humans
  • Female
  • Developmental Biology
  • Breast Neoplasms
  • Biostatistics
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology