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Metabolomics: a global biochemical approach to drug response and disease.

Publication ,  Journal Article
Kaddurah-Daouk, R; Kristal, BS; Weinshilboum, RM
Published in: Annu Rev Pharmacol Toxicol
2008

Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic science. The concept that metabolic state is representative of the overall physiologic status of the organism lies at the heart of metabolomics. Metabolomic studies capture global biochemical events by assaying thousands of small molecules in cells, tissues, organs, or biological fluids-followed by the application of informatic techniques to define metabolomic signatures. Metabolomic studies can lead to enhanced understanding of disease mechanisms and to new diagnostic markers as well as enhanced understanding of mechanisms for drug or xenobiotic effect and increased ability to predict individual variation in drug response phenotypes (pharmacometabolomics). This review outlines the conceptual basis for metabolomics as well as analytical and informatic techniques used to study the metabolome and to define metabolomic signatures. It also highlights potential metabolomic applications to pharmacology and clinical pharmacology.

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Published In

Annu Rev Pharmacol Toxicol

DOI

ISSN

0362-1642

Publication Date

2008

Volume

48

Start / End Page

653 / 683

Location

United States

Related Subject Headings

  • Systems Biology
  • Phenotype
  • Pharmacology & Pharmacy
  • Pharmaceutical Preparations
  • Metabolism
  • Medical Informatics
  • Humans
  • Chemistry Techniques, Analytical
  • Biomedical Research
  • Animals
 

Citation

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MLA
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Kaddurah-Daouk, R., Kristal, B. S., & Weinshilboum, R. M. (2008). Metabolomics: a global biochemical approach to drug response and disease. Annu Rev Pharmacol Toxicol, 48, 653–683. https://doi.org/10.1146/annurev.pharmtox.48.113006.094715
Kaddurah-Daouk, Rima, Bruce S. Kristal, and Richard M. Weinshilboum. “Metabolomics: a global biochemical approach to drug response and disease.Annu Rev Pharmacol Toxicol 48 (2008): 653–83. https://doi.org/10.1146/annurev.pharmtox.48.113006.094715.
Kaddurah-Daouk R, Kristal BS, Weinshilboum RM. Metabolomics: a global biochemical approach to drug response and disease. Annu Rev Pharmacol Toxicol. 2008;48:653–83.
Kaddurah-Daouk, Rima, et al. “Metabolomics: a global biochemical approach to drug response and disease.Annu Rev Pharmacol Toxicol, vol. 48, 2008, pp. 653–83. Pubmed, doi:10.1146/annurev.pharmtox.48.113006.094715.
Kaddurah-Daouk R, Kristal BS, Weinshilboum RM. Metabolomics: a global biochemical approach to drug response and disease. Annu Rev Pharmacol Toxicol. 2008;48:653–683.

Published In

Annu Rev Pharmacol Toxicol

DOI

ISSN

0362-1642

Publication Date

2008

Volume

48

Start / End Page

653 / 683

Location

United States

Related Subject Headings

  • Systems Biology
  • Phenotype
  • Pharmacology & Pharmacy
  • Pharmaceutical Preparations
  • Metabolism
  • Medical Informatics
  • Humans
  • Chemistry Techniques, Analytical
  • Biomedical Research
  • Animals