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Multiple roles of ATM in monitoring and maintaining DNA integrity.

Publication ,  Journal Article
Derheimer, FA; Kastan, MB
Published in: FEBS Lett
September 10, 2010

The ability of our cells to maintain genomic integrity is fundamental for protection from cancer development. Central to this process is the ability of cells to recognize and repair DNA damage and progress through the cell cycle in a regulated and orderly manner. In addition, protection of chromosome ends through the proper assembly of telomeres prevents loss of genetic information and aberrant chromosome fusions. Cells derived from patients with ataxia-telangiectasia (A-T) show defects in cell cycle regulation, abnormal responses to DNA breakage, and chromosomal end-to-end fusions. The identification and characterization of the ATM (ataxia-telangiectasia, mutated) gene product has provided an essential tool for researchers in elucidating cellular mechanisms involved in cell cycle control, DNA repair, and chromosomal stability.

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Published In

FEBS Lett

DOI

EISSN

1873-3468

Publication Date

September 10, 2010

Volume

584

Issue

17

Start / End Page

3675 / 3681

Location

England

Related Subject Headings

  • Transcriptional Activation
  • Protein Serine-Threonine Kinases
  • Humans
  • Genomic Instability
  • Genetic Diseases, Inborn
  • DNA Repair
  • DNA Damage
  • Cell Cycle
  • Biochemistry & Molecular Biology
  • Ataxia Telangiectasia
 

Citation

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Derheimer, F. A., & Kastan, M. B. (2010). Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett, 584(17), 3675–3681. https://doi.org/10.1016/j.febslet.2010.05.031
Derheimer, Frederick A., and Michael B. Kastan. “Multiple roles of ATM in monitoring and maintaining DNA integrity.FEBS Lett 584, no. 17 (September 10, 2010): 3675–81. https://doi.org/10.1016/j.febslet.2010.05.031.
Derheimer FA, Kastan MB. Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett. 2010 Sep 10;584(17):3675–81.
Derheimer, Frederick A., and Michael B. Kastan. “Multiple roles of ATM in monitoring and maintaining DNA integrity.FEBS Lett, vol. 584, no. 17, Sept. 2010, pp. 3675–81. Pubmed, doi:10.1016/j.febslet.2010.05.031.
Derheimer FA, Kastan MB. Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett. 2010 Sep 10;584(17):3675–3681.
Journal cover image

Published In

FEBS Lett

DOI

EISSN

1873-3468

Publication Date

September 10, 2010

Volume

584

Issue

17

Start / End Page

3675 / 3681

Location

England

Related Subject Headings

  • Transcriptional Activation
  • Protein Serine-Threonine Kinases
  • Humans
  • Genomic Instability
  • Genetic Diseases, Inborn
  • DNA Repair
  • DNA Damage
  • Cell Cycle
  • Biochemistry & Molecular Biology
  • Ataxia Telangiectasia