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A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia.

Publication ,  Journal Article
Sandlund, JT; Kastan, MB; Kennedy, W; Behm, F; Entrekin, E; Pui, C-H; Kalwinsky, DT; Raimondi, SC
Published in: Cancer Genet Cytogenet
July 1, 2006

Translocations involving 3q27 that affect the BCL6 gene are common and specific chromosomal abnormalities in B-cell precursor non-Hodgkin lymphoma (mainly diffuse large-cell and follicular lymphoma), but they have not been reported in Burkitt lymphoma. Here, we describe a case in which a BCL6 rearrangement and additional complex cytogenetic abnormalities occurred in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. Although cytogenetic analysis of the bone marrow revealed clonal abnormalities of chromosome arms 8q and 14p and other subclonal abnormalities, the t(8;14) or its variants typically associated with Burkitt lymphoma were not observed. Fluorescence in situ hybridization with locus-specific probes and multicolor spectral karyotyping demonstrated a complex pattern of chromosomal rearrangements leading to a subtle t(3;8)(q27;q24.1) that rearranged BCL6 and placed it adjacent to MYC. We speculate that this genetic lesion occurred as a result of chromosomal instability due to the underlying disease.

Duke Scholars

Published In

Cancer Genet Cytogenet

DOI

ISSN

0165-4608

Publication Date

July 1, 2006

Volume

168

Issue

1

Start / End Page

69 / 72

Location

United States

Related Subject Headings

  • Translocation, Genetic
  • Proto-Oncogene Proteins c-bcl-6
  • Oncology & Carcinogenesis
  • Karyotyping
  • In Situ Hybridization, Fluorescence
  • Humans
  • Genes, myc
  • Female
  • DNA-Binding Proteins
  • Chromosomes, Human, Pair 8
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sandlund, J. T., Kastan, M. B., Kennedy, W., Behm, F., Entrekin, E., Pui, C.-H., … Raimondi, S. C. (2006). A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. Cancer Genet Cytogenet, 168(1), 69–72. https://doi.org/10.1016/j.cancergencyto.2005.12.013
Sandlund, John T., Michael B. Kastan, Wren Kennedy, Frederick Behm, Elaine Entrekin, Ching-Hon Pui, David T. Kalwinsky, and Susana C. Raimondi. “A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia.Cancer Genet Cytogenet 168, no. 1 (July 1, 2006): 69–72. https://doi.org/10.1016/j.cancergencyto.2005.12.013.
Sandlund JT, Kastan MB, Kennedy W, Behm F, Entrekin E, Pui C-H, et al. A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. Cancer Genet Cytogenet. 2006 Jul 1;168(1):69–72.
Sandlund, John T., et al. “A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia.Cancer Genet Cytogenet, vol. 168, no. 1, July 2006, pp. 69–72. Pubmed, doi:10.1016/j.cancergencyto.2005.12.013.
Sandlund JT, Kastan MB, Kennedy W, Behm F, Entrekin E, Pui C-H, Kalwinsky DT, Raimondi SC. A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. Cancer Genet Cytogenet. 2006 Jul 1;168(1):69–72.
Journal cover image

Published In

Cancer Genet Cytogenet

DOI

ISSN

0165-4608

Publication Date

July 1, 2006

Volume

168

Issue

1

Start / End Page

69 / 72

Location

United States

Related Subject Headings

  • Translocation, Genetic
  • Proto-Oncogene Proteins c-bcl-6
  • Oncology & Carcinogenesis
  • Karyotyping
  • In Situ Hybridization, Fluorescence
  • Humans
  • Genes, myc
  • Female
  • DNA-Binding Proteins
  • Chromosomes, Human, Pair 8