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Cell-cycle checkpoints and cancer.

Publication ,  Journal Article
Kastan, MB; Bartek, J
Published in: Nature
November 18, 2004

All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical determinants of whether that individual will develop cancer. These cellular responses are also important for determining toxicities and responses to current cancer therapies, most of which target the DNA.

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Published In

Nature

DOI

EISSN

1476-4687

Publication Date

November 18, 2004

Volume

432

Issue

7015

Start / End Page

316 / 323

Location

England

Related Subject Headings

  • Signal Transduction
  • Neoplasms
  • Humans
  • General Science & Technology
  • DNA Damage
  • Cell Cycle
  • Animals
 

Citation

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Kastan, M. B., & Bartek, J. (2004). Cell-cycle checkpoints and cancer. Nature, 432(7015), 316–323. https://doi.org/10.1038/nature03097
Kastan, Michael B., and Jiri Bartek. “Cell-cycle checkpoints and cancer.Nature 432, no. 7015 (November 18, 2004): 316–23. https://doi.org/10.1038/nature03097.
Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature. 2004 Nov 18;432(7015):316–23.
Kastan, Michael B., and Jiri Bartek. “Cell-cycle checkpoints and cancer.Nature, vol. 432, no. 7015, Nov. 2004, pp. 316–23. Pubmed, doi:10.1038/nature03097.
Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature. 2004 Nov 18;432(7015):316–323.
Journal cover image

Published In

Nature

DOI

EISSN

1476-4687

Publication Date

November 18, 2004

Volume

432

Issue

7015

Start / End Page

316 / 323

Location

England

Related Subject Headings

  • Signal Transduction
  • Neoplasms
  • Humans
  • General Science & Technology
  • DNA Damage
  • Cell Cycle
  • Animals