Skip to main content
Journal cover image

Initiating cellular stress responses.

Publication ,  Journal Article
Bakkenist, CJ; Kastan, MB
Published in: Cell
July 9, 2004

The phosphoinositide 3-kinase related kinases (PIKKs) mediate responses to diverse stresses, including DNA double-strand breaks (DSBs), abnormal replication fork progression, the recognition of premature termination codons in mRNAs, and inadequate nutrient availability. Rigorous control of these kinases limits cellular damage and promotes cell viability in the presence of stress. Control mechanisms include the localization of PIKKs into multiprotein complexes at the sites of damage and mediation of protein-protein contacts such that substrates are allowed access to the PIKK catalytic domains.

Duke Scholars

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

July 9, 2004

Volume

118

Issue

1

Start / End Page

9 / 17

Location

United States

Related Subject Headings

  • Substrate Specificity
  • Stress, Physiological
  • Protein Structure, Tertiary
  • Phosphatidylinositol 3-Kinases
  • Models, Biological
  • Humans
  • Enzyme Activation
  • Developmental Biology
  • DNA-Binding Proteins
  • DNA Replication
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bakkenist, C. J., & Kastan, M. B. (2004). Initiating cellular stress responses. Cell, 118(1), 9–17. https://doi.org/10.1016/j.cell.2004.06.023
Bakkenist, Christopher J., and Michael B. Kastan. “Initiating cellular stress responses.Cell 118, no. 1 (July 9, 2004): 9–17. https://doi.org/10.1016/j.cell.2004.06.023.
Bakkenist CJ, Kastan MB. Initiating cellular stress responses. Cell. 2004 Jul 9;118(1):9–17.
Bakkenist, Christopher J., and Michael B. Kastan. “Initiating cellular stress responses.Cell, vol. 118, no. 1, July 2004, pp. 9–17. Pubmed, doi:10.1016/j.cell.2004.06.023.
Bakkenist CJ, Kastan MB. Initiating cellular stress responses. Cell. 2004 Jul 9;118(1):9–17.
Journal cover image

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

July 9, 2004

Volume

118

Issue

1

Start / End Page

9 / 17

Location

United States

Related Subject Headings

  • Substrate Specificity
  • Stress, Physiological
  • Protein Structure, Tertiary
  • Phosphatidylinositol 3-Kinases
  • Models, Biological
  • Humans
  • Enzyme Activation
  • Developmental Biology
  • DNA-Binding Proteins
  • DNA Replication