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ATM--a key determinant of multiple cellular responses to irradiation.

Publication ,  Journal Article
Kastan, MB; Lim, DS; Kim, ST; Yang, D
Published in: Acta Oncol
2001

Ataxia-telangiectasia is a rare clinical disorder manifesting a variety of different abnormalities, including progressive neurodegeneration, increased cancer incidence, immune deficiency, sterility, and extreme radiosensitivity. Recent studies have demonstrated that the defective gene product in this disease, ATM, is a protein kinase. The identification of several different substrates for this kinase is beginning to explain the wide array of different physiologic abnormalities that occur when this gene product is dysfunctional. Since the ATM protein is a critical signaling molecule in the cellular response to ionizing irradiation, the identification of these substrates also results in elucidation of the steps involved in a number of different cellular signaling pathways initiated by irradiation. Such insights also result in the identification of potential new targets for enhancing the efficacy of radiation therapy.

Duke Scholars

Published In

Acta Oncol

DOI

ISSN

0284-186X

Publication Date

2001

Volume

40

Issue

6

Start / End Page

686 / 688

Location

England

Related Subject Headings

  • Tumor Suppressor Proteins
  • Signal Transduction
  • Protein Serine-Threonine Kinases
  • Oncology & Carcinogenesis
  • Humans
  • DNA-Binding Proteins
  • DNA Damage
  • Cell Survival
  • Cell Cycle Proteins
  • Ataxia Telangiectasia Mutated Proteins
 

Citation

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MLA
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Kastan, M. B., Lim, D. S., Kim, S. T., & Yang, D. (2001). ATM--a key determinant of multiple cellular responses to irradiation. Acta Oncol, 40(6), 686–688. https://doi.org/10.1080/02841860152619089
Kastan, M. B., D. S. Lim, S. T. Kim, and D. Yang. “ATM--a key determinant of multiple cellular responses to irradiation.Acta Oncol 40, no. 6 (2001): 686–88. https://doi.org/10.1080/02841860152619089.
Kastan MB, Lim DS, Kim ST, Yang D. ATM--a key determinant of multiple cellular responses to irradiation. Acta Oncol. 2001;40(6):686–8.
Kastan, M. B., et al. “ATM--a key determinant of multiple cellular responses to irradiation.Acta Oncol, vol. 40, no. 6, 2001, pp. 686–88. Pubmed, doi:10.1080/02841860152619089.
Kastan MB, Lim DS, Kim ST, Yang D. ATM--a key determinant of multiple cellular responses to irradiation. Acta Oncol. 2001;40(6):686–688.
Journal cover image

Published In

Acta Oncol

DOI

ISSN

0284-186X

Publication Date

2001

Volume

40

Issue

6

Start / End Page

686 / 688

Location

England

Related Subject Headings

  • Tumor Suppressor Proteins
  • Signal Transduction
  • Protein Serine-Threonine Kinases
  • Oncology & Carcinogenesis
  • Humans
  • DNA-Binding Proteins
  • DNA Damage
  • Cell Survival
  • Cell Cycle Proteins
  • Ataxia Telangiectasia Mutated Proteins