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Cellular survival pathways and resistance to cancer therapy.

Publication ,  Journal Article
Dennis, PA; Kastan, MB
Published in: Drug Resist Updat
1998

Chemotherapy and irradiation induce programmed cell death (apoptosis) in their target cells. Dysregulated apoptosis is a feature that is selected for during tumor formation and contributes to therapeutic resistance. Cell survival in the face of cytotoxic therapy is dictated by both internal properties of the cell, such as status of components of the apoptotic machinery, and its extracellular milieu, such as extracellular matrix (ECM) and growth factor receptor expression and signaling. The importance of extracellular survival signals as key regulators of apoptosis is now being recognized by the ability of growth factors (GFs), GF receptors (GFRs), and GFR signaling to promote cellular survival. GFs can mitigate or abrogate the effectiveness of cancer therapy and protect against other cellular insults. Because survival signals generated by different extracellular sources converge at key molecules, new molecular targets have been identified which could be exploited to maximize the effectiveness of cytotoxic cancer therapy.

Duke Scholars

Published In

Drug Resist Updat

DOI

ISSN

1368-7646

Publication Date

1998

Volume

1

Issue

5

Start / End Page

301 / 309

Location

Scotland

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3107 Microbiology
  • 3101 Biochemistry and cell biology
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1108 Medical Microbiology
  • 0605 Microbiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dennis, P. A., & Kastan, M. B. (1998). Cellular survival pathways and resistance to cancer therapy. Drug Resist Updat, 1(5), 301–309. https://doi.org/10.1016/s1368-7646(98)80046-0
Dennis, P. A., and M. B. Kastan. “Cellular survival pathways and resistance to cancer therapy.Drug Resist Updat 1, no. 5 (1998): 301–9. https://doi.org/10.1016/s1368-7646(98)80046-0.
Dennis PA, Kastan MB. Cellular survival pathways and resistance to cancer therapy. Drug Resist Updat. 1998;1(5):301–9.
Dennis, P. A., and M. B. Kastan. “Cellular survival pathways and resistance to cancer therapy.Drug Resist Updat, vol. 1, no. 5, 1998, pp. 301–09. Pubmed, doi:10.1016/s1368-7646(98)80046-0.
Dennis PA, Kastan MB. Cellular survival pathways and resistance to cancer therapy. Drug Resist Updat. 1998;1(5):301–309.
Journal cover image

Published In

Drug Resist Updat

DOI

ISSN

1368-7646

Publication Date

1998

Volume

1

Issue

5

Start / End Page

301 / 309

Location

Scotland

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3107 Microbiology
  • 3101 Biochemistry and cell biology
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1108 Medical Microbiology
  • 0605 Microbiology