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The effects of inhomogeneous boundary dilution on the coating flow of an anti-HIV microbicide vehicle.

Publication ,  Journal Article
Tasoglu, S; Peters, JJ; Park, SC; Verguet, S; Katz, DF; Szeri, AJ
Published in: Physics of fluids (Woodbury, N.Y. : 1994)
September 2011

A recent study in South Africa has confirmed, for the first time, that a vaginal gel formulation of the antiretroviral drug Tenofovir, when topically applied, significantly inhibits sexual HIV transmission to women [Karim et al., Science 329, 1168 (2010)]. However, the gel for this drug and anti-HIV microbicide gels in general have not been designed using an understanding of how gel spreading and retention in the vagina govern successful drug delivery. Elastohydrodynamic lubrication theory can be applied to model spreading of microbicide gels [Szeri et al., Phys. Fluids 20, 083101 (2008)]. This should incorporate the full rheological behavior of a gel, including how rheological properties change due to contact with, and dilution by, ambient vaginal fluids. Here, we extend our initial analysis, incorporating the effects of gel dilution due to contact with vaginal fluid produced at the gel-tissue interface. Our original model is supplemented with a convective-diffusive transport equation to characterize water transport into the gel and, thus, local gel dilution. The problem is solved using a multi-step scheme in a moving domain. The association between local dilution of gel and rheological properties is obtained experimentally, delineating the way constitutive parameters of a shear-thinning gel are modified by dilution. Results show that dilution accelerates the coating flow by creating a slippery region near the vaginal wall akin to a dilution boundary layer, especially if the boundary flux exceeds a certain value. On the other hand, if the diffusion coefficient of boundary fluid is increased, the slippery region diminishes in extent and the overall rate of gel spreading decreases.

Duke Scholars

Published In

Physics of fluids (Woodbury, N.Y. : 1994)

DOI

EISSN

1089-7666

ISSN

1070-6631

Publication Date

September 2011

Volume

23

Issue

9

Start / End Page

93101 / 931019

Related Subject Headings

  • Fluids & Plasmas
  • 51 Physical sciences
  • 49 Mathematical sciences
  • 40 Engineering
  • 09 Engineering
  • 02 Physical Sciences
  • 01 Mathematical Sciences
 

Citation

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Tasoglu, S., Peters, J. J., Park, S. C., Verguet, S., Katz, D. F., & Szeri, A. J. (2011). The effects of inhomogeneous boundary dilution on the coating flow of an anti-HIV microbicide vehicle. Physics of Fluids (Woodbury, N.Y. : 1994), 23(9), 93101–931019. https://doi.org/10.1063/1.3633337
Tasoglu, Savas, Jennifer J. Peters, Su Chan Park, Stéphane Verguet, David F. Katz, and Andrew J. Szeri. “The effects of inhomogeneous boundary dilution on the coating flow of an anti-HIV microbicide vehicle.Physics of Fluids (Woodbury, N.Y. : 1994) 23, no. 9 (September 2011): 93101–19. https://doi.org/10.1063/1.3633337.
Tasoglu S, Peters JJ, Park SC, Verguet S, Katz DF, Szeri AJ. The effects of inhomogeneous boundary dilution on the coating flow of an anti-HIV microbicide vehicle. Physics of fluids (Woodbury, NY : 1994). 2011 Sep;23(9):93101–931019.
Tasoglu, Savas, et al. “The effects of inhomogeneous boundary dilution on the coating flow of an anti-HIV microbicide vehicle.Physics of Fluids (Woodbury, N.Y. : 1994), vol. 23, no. 9, Sept. 2011, pp. 93101–931019. Epmc, doi:10.1063/1.3633337.
Tasoglu S, Peters JJ, Park SC, Verguet S, Katz DF, Szeri AJ. The effects of inhomogeneous boundary dilution on the coating flow of an anti-HIV microbicide vehicle. Physics of fluids (Woodbury, NY : 1994). 2011 Sep;23(9):93101–931019.

Published In

Physics of fluids (Woodbury, N.Y. : 1994)

DOI

EISSN

1089-7666

ISSN

1070-6631

Publication Date

September 2011

Volume

23

Issue

9

Start / End Page

93101 / 931019

Related Subject Headings

  • Fluids & Plasmas
  • 51 Physical sciences
  • 49 Mathematical sciences
  • 40 Engineering
  • 09 Engineering
  • 02 Physical Sciences
  • 01 Mathematical Sciences