Skip to main content
Journal cover image

Design of a semisolid vaginal microbicide gel by relating composition to properties and performance.

Publication ,  Journal Article
Mahalingam, A; Smith, E; Fabian, J; Damian, FR; Peters, JJ; Clark, MR; Friend, DR; Katz, DF; Kiser, PF
Published in: Pharmaceutical research
November 2010

Develop a preclinical in vitro algorithm enabling de novo design of semisolid vaginal drug delivery gels, by using biomechanical modeling of gel spreading in the vaginal canal and empirically relating gel composition to mechanical properties and predicted performance.Gel performance was defined through a multivariate objective function constructed from gels' mechanical properties and selected performance criteria for gel spreading within the vaginal canal. Mixture design of experiment was used to establish a semi-empirical relationship linking composition-property and property-performance relationships for gels with varying concentrations of hydroxyethylcellulose and Carbopol 974P. This permits definition of a local optimum for gel composition and volume of administration, within a defined gel composition space.Rheological behavior and, consequently, the value of the objective function varied broadly with composition. The algorithm indicated a 3.0 wt% HEC gel as the near optimal composition for a 3.5 mL applied volume for gels designed to spread throughout the vagina.The algorithm introduced herein is a novel tool that facilitates an understanding of the composition-property-performance relationship for vaginal semisolid drug delivery gels. This approach has promise as a scientific methodology for evaluation and optimization of vaginal gels prior to in vivo investigations.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Pharmaceutical research

DOI

EISSN

1573-904X

ISSN

0724-8741

Publication Date

November 2010

Volume

27

Issue

11

Start / End Page

2478 / 2491

Related Subject Headings

  • Vagina
  • Pharmacology & Pharmacy
  • Humans
  • Gels
  • Female
  • Anti-Infective Agents
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mahalingam, A., Smith, E., Fabian, J., Damian, F. R., Peters, J. J., Clark, M. R., … Kiser, P. F. (2010). Design of a semisolid vaginal microbicide gel by relating composition to properties and performance. Pharmaceutical Research, 27(11), 2478–2491. https://doi.org/10.1007/s11095-010-0244-1
Mahalingam, Alamelu, Eric Smith, Judit Fabian, Festo R. Damian, Jennifer J. Peters, Meredith R. Clark, David R. Friend, David F. Katz, and Patrick F. Kiser. “Design of a semisolid vaginal microbicide gel by relating composition to properties and performance.Pharmaceutical Research 27, no. 11 (November 2010): 2478–91. https://doi.org/10.1007/s11095-010-0244-1.
Mahalingam A, Smith E, Fabian J, Damian FR, Peters JJ, Clark MR, et al. Design of a semisolid vaginal microbicide gel by relating composition to properties and performance. Pharmaceutical research. 2010 Nov;27(11):2478–91.
Mahalingam, Alamelu, et al. “Design of a semisolid vaginal microbicide gel by relating composition to properties and performance.Pharmaceutical Research, vol. 27, no. 11, Nov. 2010, pp. 2478–91. Epmc, doi:10.1007/s11095-010-0244-1.
Mahalingam A, Smith E, Fabian J, Damian FR, Peters JJ, Clark MR, Friend DR, Katz DF, Kiser PF. Design of a semisolid vaginal microbicide gel by relating composition to properties and performance. Pharmaceutical research. 2010 Nov;27(11):2478–2491.
Journal cover image

Published In

Pharmaceutical research

DOI

EISSN

1573-904X

ISSN

0724-8741

Publication Date

November 2010

Volume

27

Issue

11

Start / End Page

2478 / 2491

Related Subject Headings

  • Vagina
  • Pharmacology & Pharmacy
  • Humans
  • Gels
  • Female
  • Anti-Infective Agents
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences