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Eukaryotic mRNPs may represent posttranscriptional operons.

Publication ,  Journal Article
Keene, JD; Tenenbaum, SA
Published in: Mol Cell
June 2002

Genomic array analysis of endogenous mammalian ribonucleoproteins has recently revealed three novel findings: (1) mRNA binding proteins are associated with unique subpopulations of messages, (2) the compositions of these mRNA subsets can vary with growth conditions, and (3) the same mRNA species can be found in multiple mRNP complexes. Based on these and other findings, we propose a model of posttranscriptional gene expression in which mRNA binding proteins regulate mRNAs as subpopulations during cell growth and development. This model predicts that functionally related genes are regulated posttranscriptionally as groups by specific mRNA binding proteins that recognize sequence elements in common among the mRNAs.

Duke Scholars

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Published In

Mol Cell

DOI

ISSN

1097-2765

Publication Date

June 2002

Volume

9

Issue

6

Start / End Page

1161 / 1167

Location

United States

Related Subject Headings

  • Ribonucleoproteins
  • Regulatory Sequences, Nucleic Acid
  • RNA-Binding Proteins
  • RNA, Messenger
  • Operon
  • Models, Genetic
  • Gene Expression Regulation
  • Developmental Biology
  • Animals
  • 42 Health sciences
 

Citation

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Keene, J. D., & Tenenbaum, S. A. (2002). Eukaryotic mRNPs may represent posttranscriptional operons. Mol Cell, 9(6), 1161–1167. https://doi.org/10.1016/s1097-2765(02)00559-2
Keene, Jack D., and Scott A. Tenenbaum. “Eukaryotic mRNPs may represent posttranscriptional operons.Mol Cell 9, no. 6 (June 2002): 1161–67. https://doi.org/10.1016/s1097-2765(02)00559-2.
Keene JD, Tenenbaum SA. Eukaryotic mRNPs may represent posttranscriptional operons. Mol Cell. 2002 Jun;9(6):1161–7.
Keene, Jack D., and Scott A. Tenenbaum. “Eukaryotic mRNPs may represent posttranscriptional operons.Mol Cell, vol. 9, no. 6, June 2002, pp. 1161–67. Pubmed, doi:10.1016/s1097-2765(02)00559-2.
Keene JD, Tenenbaum SA. Eukaryotic mRNPs may represent posttranscriptional operons. Mol Cell. 2002 Jun;9(6):1161–1167.
Journal cover image

Published In

Mol Cell

DOI

ISSN

1097-2765

Publication Date

June 2002

Volume

9

Issue

6

Start / End Page

1161 / 1167

Location

United States

Related Subject Headings

  • Ribonucleoproteins
  • Regulatory Sequences, Nucleic Acid
  • RNA-Binding Proteins
  • RNA, Messenger
  • Operon
  • Models, Genetic
  • Gene Expression Regulation
  • Developmental Biology
  • Animals
  • 42 Health sciences