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Transcription as a source of genome instability.

Publication ,  Journal Article
Kim, N; Jinks-Robertson, S
Published in: Nat Rev Genet
February 14, 2012

Alterations in genome sequence and structure contribute to somatic disease, affect the fitness of subsequent generations and drive evolutionary processes. The crucial roles of highly accurate replication and efficient repair in maintaining overall genome integrity are well-known, but the more localized stability costs that are associated with transcribing DNA into RNA molecules are less appreciated. Here we review the diverse ways in which the essential process of transcription alters the underlying DNA template and thereby modifies the genetic landscape.

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Published In

Nat Rev Genet

DOI

EISSN

1471-0064

Publication Date

February 14, 2012

Volume

13

Issue

3

Start / End Page

204 / 214

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Humans
  • Genomic Instability
  • Developmental Biology
  • DNA Replication
  • DNA Repair
  • DNA
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 0607 Plant Biology
 

Citation

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Kim, N., & Jinks-Robertson, S. (2012). Transcription as a source of genome instability. Nat Rev Genet, 13(3), 204–214. https://doi.org/10.1038/nrg3152
Kim, Nayun, and Sue Jinks-Robertson. “Transcription as a source of genome instability.Nat Rev Genet 13, no. 3 (February 14, 2012): 204–14. https://doi.org/10.1038/nrg3152.
Kim N, Jinks-Robertson S. Transcription as a source of genome instability. Nat Rev Genet. 2012 Feb 14;13(3):204–14.
Kim, Nayun, and Sue Jinks-Robertson. “Transcription as a source of genome instability.Nat Rev Genet, vol. 13, no. 3, Feb. 2012, pp. 204–14. Pubmed, doi:10.1038/nrg3152.
Kim N, Jinks-Robertson S. Transcription as a source of genome instability. Nat Rev Genet. 2012 Feb 14;13(3):204–214.

Published In

Nat Rev Genet

DOI

EISSN

1471-0064

Publication Date

February 14, 2012

Volume

13

Issue

3

Start / End Page

204 / 214

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Humans
  • Genomic Instability
  • Developmental Biology
  • DNA Replication
  • DNA Repair
  • DNA
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 0607 Plant Biology