Skip to main content

FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy.

Publication ,  Journal Article
Snyder, A; Alsauskas, Z; Gong, P; Rosenstiel, PE; Klotman, ME; Klotman, PE; Ross, MJ
Published in: J Virol
November 2009

Human immunodeficiency virus (HIV)-associated nephropathy is a significant cause of morbidity and mortality in HIV-infected persons. Vpr-induced cell cycle dysregulation and apoptosis of renal tubular epithelial cells are important components of the pathogenesis of HIV-associated nephropathy (HIVAN). FAT10 is a ubiquitin-like protein that is upregulated in renal tubular epithelial cells in HIVAN. In these studies, we report that Vpr induces increased expression of FAT10 in tubular cells and that inhibition of FAT10 expression prevents Vpr-induced apoptosis in human and murine tubular cells. Moreover, we found that Vpr interacts with FAT10 and that these proteins colocalize at mitochondria. These studies establish FAT10 as a novel mediator of Vpr-induced cell death.

Duke Scholars

Published In

J Virol

DOI

EISSN

1098-5514

Publication Date

November 2009

Volume

83

Issue

22

Start / End Page

11983 / 11988

Location

United States

Related Subject Headings

  • vpr Gene Products, Human Immunodeficiency Virus
  • Virology
  • Ubiquitins
  • Mice
  • Humans
  • HIV-1
  • Cell Line
  • Cell Cycle
  • Apoptosis
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Snyder, A., Alsauskas, Z., Gong, P., Rosenstiel, P. E., Klotman, M. E., Klotman, P. E., & Ross, M. J. (2009). FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy. J Virol, 83(22), 11983–11988. https://doi.org/10.1128/JVI.00034-09
Snyder, Alexandra, Zygimantas Alsauskas, Pengfei Gong, Paul E. Rosenstiel, Mary E. Klotman, Paul E. Klotman, and Michael J. Ross. “FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy.J Virol 83, no. 22 (November 2009): 11983–88. https://doi.org/10.1128/JVI.00034-09.
Snyder A, Alsauskas Z, Gong P, Rosenstiel PE, Klotman ME, Klotman PE, et al. FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy. J Virol. 2009 Nov;83(22):11983–8.
Snyder, Alexandra, et al. “FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy.J Virol, vol. 83, no. 22, Nov. 2009, pp. 11983–88. Pubmed, doi:10.1128/JVI.00034-09.
Snyder A, Alsauskas Z, Gong P, Rosenstiel PE, Klotman ME, Klotman PE, Ross MJ. FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy. J Virol. 2009 Nov;83(22):11983–11988.

Published In

J Virol

DOI

EISSN

1098-5514

Publication Date

November 2009

Volume

83

Issue

22

Start / End Page

11983 / 11988

Location

United States

Related Subject Headings

  • vpr Gene Products, Human Immunodeficiency Virus
  • Virology
  • Ubiquitins
  • Mice
  • Humans
  • HIV-1
  • Cell Line
  • Cell Cycle
  • Apoptosis
  • Animals