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SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission.

Publication ,  Journal Article
Chang, TL; Teleshova, N; Rapista, A; Paluch, M; Anderson, RA; Waller, DP; Zaneveld, LJD; Granelli-Piperno, A; Klotman, ME
Published in: FEBS Lett
October 2, 2007

SAMMA, a mandelic acid condensation polymer, exhibits a broad antimicrobial activity against several sexually transmitted pathogens including human immunodeficiency virus (HIV). Here we demonstrated that SAMMA suppressed HIV transmission by dendritic cells (DCs), one of the first target cells for primary infection. The greatest inhibitory effect was achieved when SAMMA was present during the co-culture with target cells. The inhibitory effect of SAMMA on DC-mediated HIV transmission was not due to cytotoxicity. Analysis of the level of DC-associated HIV p24 antigen revealed that SAMMA prevented HIV internalization by DCs when the virus was pre-incubated with the compound. In contrast, pre-incubation of DCs with SAMMA followed by wash-off did not affect the amount of cell-associated HIV p24 antigen. In addition, SAMMA blocked HIV glycoprotein-mediated cell-cell fusion. This study suggests that SAMMA prevents HIV infection through multiple mechanisms.

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Published In

FEBS Lett

DOI

ISSN

0014-5793

Publication Date

October 2, 2007

Volume

581

Issue

24

Start / End Page

4596 / 4602

Location

England

Related Subject Headings

  • Virus Internalization
  • Viral Proteins
  • Polymers
  • Mandelic Acids
  • Humans
  • HIV Infections
  • Glycoproteins
  • Dendritic Cells
  • Cells, Cultured
  • Biochemistry & Molecular Biology
 

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Chang, T. L., Teleshova, N., Rapista, A., Paluch, M., Anderson, R. A., Waller, D. P., … Klotman, M. E. (2007). SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission. FEBS Lett, 581(24), 4596–4602. https://doi.org/10.1016/j.febslet.2007.08.048
Chang, Theresa L., Natalia Teleshova, Aprille Rapista, Maciej Paluch, Robert A. Anderson, Donald P. Waller, Lourens J. D. Zaneveld, Angela Granelli-Piperno, and Mary E. Klotman. “SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission.FEBS Lett 581, no. 24 (October 2, 2007): 4596–4602. https://doi.org/10.1016/j.febslet.2007.08.048.
Chang TL, Teleshova N, Rapista A, Paluch M, Anderson RA, Waller DP, et al. SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission. FEBS Lett. 2007 Oct 2;581(24):4596–602.
Chang, Theresa L., et al. “SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission.FEBS Lett, vol. 581, no. 24, Oct. 2007, pp. 4596–602. Pubmed, doi:10.1016/j.febslet.2007.08.048.
Chang TL, Teleshova N, Rapista A, Paluch M, Anderson RA, Waller DP, Zaneveld LJD, Granelli-Piperno A, Klotman ME. SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission. FEBS Lett. 2007 Oct 2;581(24):4596–4602.
Journal cover image

Published In

FEBS Lett

DOI

ISSN

0014-5793

Publication Date

October 2, 2007

Volume

581

Issue

24

Start / End Page

4596 / 4602

Location

England

Related Subject Headings

  • Virus Internalization
  • Viral Proteins
  • Polymers
  • Mandelic Acids
  • Humans
  • HIV Infections
  • Glycoproteins
  • Dendritic Cells
  • Cells, Cultured
  • Biochemistry & Molecular Biology