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Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element.

Publication ,  Journal Article
Li, G; Lisziewicz, J; Sun, D; Zon, G; Daefler, S; Wong-Staal, F; Gallo, RC; Klotman, ME
Published in: J Virol
November 1993

The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. We demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy.

Duke Scholars

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

November 1993

Volume

67

Issue

11

Start / End Page

6882 / 6888

Location

United States

Related Subject Headings

  • rev Gene Products, Human Immunodeficiency Virus
  • Virus Replication
  • Virology
  • Structure-Activity Relationship
  • Regulatory Sequences, Nucleic Acid
  • RNA, Viral
  • Oligonucleotides, Antisense
  • Nucleic Acid Conformation
  • Molecular Sequence Data
  • In Vitro Techniques
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, G., Lisziewicz, J., Sun, D., Zon, G., Daefler, S., Wong-Staal, F., … Klotman, M. E. (1993). Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element. J Virol, 67(11), 6882–6888. https://doi.org/10.1128/JVI.67.11.6882-6888.1993
Li, G., J. Lisziewicz, D. Sun, G. Zon, S. Daefler, F. Wong-Staal, R. C. Gallo, and M. E. Klotman. “Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element.J Virol 67, no. 11 (November 1993): 6882–88. https://doi.org/10.1128/JVI.67.11.6882-6888.1993.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

November 1993

Volume

67

Issue

11

Start / End Page

6882 / 6888

Location

United States

Related Subject Headings

  • rev Gene Products, Human Immunodeficiency Virus
  • Virus Replication
  • Virology
  • Structure-Activity Relationship
  • Regulatory Sequences, Nucleic Acid
  • RNA, Viral
  • Oligonucleotides, Antisense
  • Nucleic Acid Conformation
  • Molecular Sequence Data
  • In Vitro Techniques