Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element.
Publication
, Journal Article
Li, G; Lisziewicz, J; Sun, D; Zon, G; Daefler, S; Wong-Staal, F; Gallo, RC; Klotman, ME
Published in: J Virol
November 1993
The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. We demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy.
Duke Scholars
Published In
J Virol
DOI
ISSN
0022-538X
Publication Date
November 1993
Volume
67
Issue
11
Start / End Page
6882 / 6888
Location
United States
Related Subject Headings
- rev Gene Products, Human Immunodeficiency Virus
- Virus Replication
- Virology
- Structure-Activity Relationship
- Regulatory Sequences, Nucleic Acid
- RNA, Viral
- Oligonucleotides, Antisense
- Nucleic Acid Conformation
- Molecular Sequence Data
- In Vitro Techniques
Citation
APA
Chicago
ICMJE
MLA
NLM
Li, G., Lisziewicz, J., Sun, D., Zon, G., Daefler, S., Wong-Staal, F., … Klotman, M. E. (1993). Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element. J Virol, 67(11), 6882–6888. https://doi.org/10.1128/JVI.67.11.6882-6888.1993
Li, G., J. Lisziewicz, D. Sun, G. Zon, S. Daefler, F. Wong-Staal, R. C. Gallo, and M. E. Klotman. “Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element.” J Virol 67, no. 11 (November 1993): 6882–88. https://doi.org/10.1128/JVI.67.11.6882-6888.1993.
Li G, Lisziewicz J, Sun D, Zon G, Daefler S, Wong-Staal F, et al. Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element. J Virol. 1993 Nov;67(11):6882–8.
Li, G., et al. “Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element.” J Virol, vol. 67, no. 11, Nov. 1993, pp. 6882–88. Pubmed, doi:10.1128/JVI.67.11.6882-6888.1993.
Li G, Lisziewicz J, Sun D, Zon G, Daefler S, Wong-Staal F, Gallo RC, Klotman ME. Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element. J Virol. 1993 Nov;67(11):6882–6888.
Published In
J Virol
DOI
ISSN
0022-538X
Publication Date
November 1993
Volume
67
Issue
11
Start / End Page
6882 / 6888
Location
United States
Related Subject Headings
- rev Gene Products, Human Immunodeficiency Virus
- Virus Replication
- Virology
- Structure-Activity Relationship
- Regulatory Sequences, Nucleic Acid
- RNA, Viral
- Oligonucleotides, Antisense
- Nucleic Acid Conformation
- Molecular Sequence Data
- In Vitro Techniques