Mcl-1 rescues a glitch in the matrix.
Publication
, Journal Article
Andersen, JL; Kornbluth, S
Published in: Nature cell biology
May 2012
Bcl-2 family proteins are known to control cell death and influence mitochondrial function. The function of Mcl-1, an anti-apoptotic Bcl-2 protein, is now shown to depend on its subcellular localization. Mcl-1 at the mitochondrial outer membrane inhibits mitochondrial permeabilization to block apoptosis. However, a cleaved form of Mcl-1 localizes to the mitochondrial matrix and controls inner mitochondrial morphology and oxidative phosphorylation, without directly modulating apoptosis.
Duke Scholars
Published In
Nature cell biology
DOI
EISSN
1476-4679
ISSN
1465-7392
Publication Date
May 2012
Volume
14
Issue
6
Start / End Page
563 / 565
Related Subject Headings
- Proto-Oncogene Proteins c-bcl-2
- Myeloid Cell Leukemia Sequence 1 Protein
- Mitochondria
- Humans
- Developmental Biology
- Animals
- 3101 Biochemistry and cell biology
- 11 Medical and Health Sciences
- 06 Biological Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Andersen, J. L., & Kornbluth, S. (2012). Mcl-1 rescues a glitch in the matrix. Nature Cell Biology, 14(6), 563–565. https://doi.org/10.1038/ncb2511
Andersen, Joshua L., and Sally Kornbluth. “Mcl-1 rescues a glitch in the matrix.” Nature Cell Biology 14, no. 6 (May 2012): 563–65. https://doi.org/10.1038/ncb2511.
Andersen JL, Kornbluth S. Mcl-1 rescues a glitch in the matrix. Nature cell biology. 2012 May;14(6):563–5.
Andersen, Joshua L., and Sally Kornbluth. “Mcl-1 rescues a glitch in the matrix.” Nature Cell Biology, vol. 14, no. 6, May 2012, pp. 563–65. Epmc, doi:10.1038/ncb2511.
Andersen JL, Kornbluth S. Mcl-1 rescues a glitch in the matrix. Nature cell biology. 2012 May;14(6):563–565.
Published In
Nature cell biology
DOI
EISSN
1476-4679
ISSN
1465-7392
Publication Date
May 2012
Volume
14
Issue
6
Start / End Page
563 / 565
Related Subject Headings
- Proto-Oncogene Proteins c-bcl-2
- Myeloid Cell Leukemia Sequence 1 Protein
- Mitochondria
- Humans
- Developmental Biology
- Animals
- 3101 Biochemistry and cell biology
- 11 Medical and Health Sciences
- 06 Biological Sciences