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Mcl-1 rescues a glitch in the matrix.

Publication ,  Journal Article
Andersen, JL; Kornbluth, S
Published in: Nature cell biology
May 2012

Bcl-2 family proteins are known to control cell death and influence mitochondrial function. The function of Mcl-1, an anti-apoptotic Bcl-2 protein, is now shown to depend on its subcellular localization. Mcl-1 at the mitochondrial outer membrane inhibits mitochondrial permeabilization to block apoptosis. However, a cleaved form of Mcl-1 localizes to the mitochondrial matrix and controls inner mitochondrial morphology and oxidative phosphorylation, without directly modulating apoptosis.

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Published In

Nature cell biology

DOI

EISSN

1476-4679

ISSN

1465-7392

Publication Date

May 2012

Volume

14

Issue

6

Start / End Page

563 / 565

Related Subject Headings

  • Proto-Oncogene Proteins c-bcl-2
  • Myeloid Cell Leukemia Sequence 1 Protein
  • Mitochondria
  • Humans
  • Developmental Biology
  • Animals
  • 3101 Biochemistry and cell biology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

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Andersen, J. L., & Kornbluth, S. (2012). Mcl-1 rescues a glitch in the matrix. Nature Cell Biology, 14(6), 563–565. https://doi.org/10.1038/ncb2511
Andersen, Joshua L., and Sally Kornbluth. “Mcl-1 rescues a glitch in the matrix.Nature Cell Biology 14, no. 6 (May 2012): 563–65. https://doi.org/10.1038/ncb2511.
Andersen JL, Kornbluth S. Mcl-1 rescues a glitch in the matrix. Nature cell biology. 2012 May;14(6):563–5.
Andersen, Joshua L., and Sally Kornbluth. “Mcl-1 rescues a glitch in the matrix.Nature Cell Biology, vol. 14, no. 6, May 2012, pp. 563–65. Epmc, doi:10.1038/ncb2511.
Andersen JL, Kornbluth S. Mcl-1 rescues a glitch in the matrix. Nature cell biology. 2012 May;14(6):563–565.

Published In

Nature cell biology

DOI

EISSN

1476-4679

ISSN

1465-7392

Publication Date

May 2012

Volume

14

Issue

6

Start / End Page

563 / 565

Related Subject Headings

  • Proto-Oncogene Proteins c-bcl-2
  • Myeloid Cell Leukemia Sequence 1 Protein
  • Mitochondria
  • Humans
  • Developmental Biology
  • Animals
  • 3101 Biochemistry and cell biology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences