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Life, death, and the metabolically controlled protein acetylome.

Publication ,  Journal Article
Johnson, ES; Kornbluth, S
Published in: Current opinion in cell biology
December 2012

The complex signaling pathways that control cellular fate can be intimately influenced by metabolic status. Although the ability of nutrients to influence intracellular decisions has been appreciated for some time, the complex signaling mechanisms linking metabolic inputs to cell proliferation and death are not fully understood. An emerging theme in the literature is that intracellular metabolite levels can directly influence cell fate decisions through modulation of nutrient-derived protein modifications. It appears that varying the level of intracellular metabolites can alter the abundance of post-translational modifications, both by altering the availability of donor substrates and changing the activity of the nutrient-sensitive enzymes regulating these reactions. We focus here on protein acetylation, a modification that can modulate both cell proliferation and cell death in response to changes in extracellular nutrient supply.

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Published In

Current opinion in cell biology

DOI

EISSN

1879-0410

ISSN

0955-0674

Publication Date

December 2012

Volume

24

Issue

6

Start / End Page

876 / 880

Related Subject Headings

  • Signal Transduction
  • Protein Processing, Post-Translational
  • Humans
  • Developmental Biology
  • Cells
  • Cell Survival
  • Cell Proliferation
  • Cell Death
  • Animals
  • Acetyltransferases
 

Citation

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Johnson, E. S., & Kornbluth, S. (2012). Life, death, and the metabolically controlled protein acetylome. Current Opinion in Cell Biology, 24(6), 876–880. https://doi.org/10.1016/j.ceb.2012.10.002
Johnson, Erika Segear, and Sally Kornbluth. “Life, death, and the metabolically controlled protein acetylome.Current Opinion in Cell Biology 24, no. 6 (December 2012): 876–80. https://doi.org/10.1016/j.ceb.2012.10.002.
Johnson ES, Kornbluth S. Life, death, and the metabolically controlled protein acetylome. Current opinion in cell biology. 2012 Dec;24(6):876–80.
Johnson, Erika Segear, and Sally Kornbluth. “Life, death, and the metabolically controlled protein acetylome.Current Opinion in Cell Biology, vol. 24, no. 6, Dec. 2012, pp. 876–80. Epmc, doi:10.1016/j.ceb.2012.10.002.
Johnson ES, Kornbluth S. Life, death, and the metabolically controlled protein acetylome. Current opinion in cell biology. 2012 Dec;24(6):876–880.
Journal cover image

Published In

Current opinion in cell biology

DOI

EISSN

1879-0410

ISSN

0955-0674

Publication Date

December 2012

Volume

24

Issue

6

Start / End Page

876 / 880

Related Subject Headings

  • Signal Transduction
  • Protein Processing, Post-Translational
  • Humans
  • Developmental Biology
  • Cells
  • Cell Survival
  • Cell Proliferation
  • Cell Death
  • Animals
  • Acetyltransferases