The engine driving the ship: metabolic steering of cell proliferation and death.
Publication
, Journal Article
Buchakjian, MR; Kornbluth, S
Published in: Nature reviews. Molecular cell biology
October 2010
Metabolic activity is a crucial determinant of a cell's decision to proliferate or die. Although it is not fully understood how metabolic pathways such as glycolysis and the pentose phosphate pathway communicate to cell cycle and apoptotic effectors, it is clear that a complex network of signalling molecules is required to integrate metabolic inputs. D-type cyclins, cyclin-dependent kinases, the anaphase-promoting complex, p53, caspase 2 and B cell lymphoma 2 proteins, among others, have been shown to be regulated by metabolic crosstalk. Elucidating these pathways is of great importance, as metabolic aberrations and their downstream effects are known to contribute to the aetiology of cancer and degenerative disorders.
Duke Scholars
Published In
Nature reviews. Molecular cell biology
DOI
EISSN
1471-0080
ISSN
1471-0072
Publication Date
October 2010
Volume
11
Issue
10
Start / End Page
715 / 727
Related Subject Headings
- Neurodegenerative Diseases
- Neoplasms
- Insulin-Secreting Cells
- Humans
- Glycolysis
- Fatty Acids
- Extracellular Space
- Developmental Biology
- Cyclins
- Cell Division
Citation
APA
Chicago
ICMJE
MLA
NLM
Buchakjian, M. R., & Kornbluth, S. (2010). The engine driving the ship: metabolic steering of cell proliferation and death. Nature Reviews. Molecular Cell Biology, 11(10), 715–727. https://doi.org/10.1038/nrm2972
Buchakjian, Marisa R., and Sally Kornbluth. “The engine driving the ship: metabolic steering of cell proliferation and death.” Nature Reviews. Molecular Cell Biology 11, no. 10 (October 2010): 715–27. https://doi.org/10.1038/nrm2972.
Buchakjian MR, Kornbluth S. The engine driving the ship: metabolic steering of cell proliferation and death. Nature reviews Molecular cell biology. 2010 Oct;11(10):715–27.
Buchakjian, Marisa R., and Sally Kornbluth. “The engine driving the ship: metabolic steering of cell proliferation and death.” Nature Reviews. Molecular Cell Biology, vol. 11, no. 10, Oct. 2010, pp. 715–27. Epmc, doi:10.1038/nrm2972.
Buchakjian MR, Kornbluth S. The engine driving the ship: metabolic steering of cell proliferation and death. Nature reviews Molecular cell biology. 2010 Oct;11(10):715–727.
Published In
Nature reviews. Molecular cell biology
DOI
EISSN
1471-0080
ISSN
1471-0072
Publication Date
October 2010
Volume
11
Issue
10
Start / End Page
715 / 727
Related Subject Headings
- Neurodegenerative Diseases
- Neoplasms
- Insulin-Secreting Cells
- Humans
- Glycolysis
- Fatty Acids
- Extracellular Space
- Developmental Biology
- Cyclins
- Cell Division