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The engine driving the ship: metabolic steering of cell proliferation and death.

Publication ,  Journal Article
Buchakjian, MR; Kornbluth, S
Published in: Nature reviews. Molecular cell biology
October 2010

Metabolic activity is a crucial determinant of a cell's decision to proliferate or die. Although it is not fully understood how metabolic pathways such as glycolysis and the pentose phosphate pathway communicate to cell cycle and apoptotic effectors, it is clear that a complex network of signalling molecules is required to integrate metabolic inputs. D-type cyclins, cyclin-dependent kinases, the anaphase-promoting complex, p53, caspase 2 and B cell lymphoma 2 proteins, among others, have been shown to be regulated by metabolic crosstalk. Elucidating these pathways is of great importance, as metabolic aberrations and their downstream effects are known to contribute to the aetiology of cancer and degenerative disorders.

Duke Scholars

Published In

Nature reviews. Molecular cell biology

DOI

EISSN

1471-0080

ISSN

1471-0072

Publication Date

October 2010

Volume

11

Issue

10

Start / End Page

715 / 727

Related Subject Headings

  • Neurodegenerative Diseases
  • Neoplasms
  • Insulin-Secreting Cells
  • Humans
  • Glycolysis
  • Fatty Acids
  • Extracellular Space
  • Developmental Biology
  • Cyclins
  • Cell Division
 

Citation

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Buchakjian, M. R., & Kornbluth, S. (2010). The engine driving the ship: metabolic steering of cell proliferation and death. Nature Reviews. Molecular Cell Biology, 11(10), 715–727. https://doi.org/10.1038/nrm2972
Buchakjian, Marisa R., and Sally Kornbluth. “The engine driving the ship: metabolic steering of cell proliferation and death.Nature Reviews. Molecular Cell Biology 11, no. 10 (October 2010): 715–27. https://doi.org/10.1038/nrm2972.
Buchakjian MR, Kornbluth S. The engine driving the ship: metabolic steering of cell proliferation and death. Nature reviews Molecular cell biology. 2010 Oct;11(10):715–27.
Buchakjian, Marisa R., and Sally Kornbluth. “The engine driving the ship: metabolic steering of cell proliferation and death.Nature Reviews. Molecular Cell Biology, vol. 11, no. 10, Oct. 2010, pp. 715–27. Epmc, doi:10.1038/nrm2972.
Buchakjian MR, Kornbluth S. The engine driving the ship: metabolic steering of cell proliferation and death. Nature reviews Molecular cell biology. 2010 Oct;11(10):715–727.

Published In

Nature reviews. Molecular cell biology

DOI

EISSN

1471-0080

ISSN

1471-0072

Publication Date

October 2010

Volume

11

Issue

10

Start / End Page

715 / 727

Related Subject Headings

  • Neurodegenerative Diseases
  • Neoplasms
  • Insulin-Secreting Cells
  • Humans
  • Glycolysis
  • Fatty Acids
  • Extracellular Space
  • Developmental Biology
  • Cyclins
  • Cell Division