Skip to main content
Journal cover image

Caspases and kinases in a death grip.

Publication ,  Journal Article
Kurokawa, M; Kornbluth, S
Published in: Cell
September 2009

The complex process of apoptosis is orchestrated by caspases, a family of cysteine proteases with unique substrate specificities. Accumulating evidence suggests that cell death pathways are finely tuned by multiple signaling events, including direct phosphorylation of caspases, whereas kinases are often substrates of active caspases. Importantly, caspase-mediated cleavage of kinases can terminate prosurvival signaling or generate proapoptotic peptide fragments that help to execute the death program and facilitate packaging of the dying cells. Here, we review caspases as kinase substrates and kinases as caspase substrates and discuss how the balance between cell survival and cell death can be shifted through crosstalk between these two enzyme families.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cell

DOI

EISSN

1097-4172

ISSN

0092-8674

Publication Date

September 2009

Volume

138

Issue

5

Start / End Page

838 / 854

Related Subject Headings

  • Phosphotransferases
  • Phosphorylation
  • Phosphoric Monoester Hydrolases
  • Humans
  • Developmental Biology
  • Cell Cycle
  • Caspases
  • Apoptosis
  • Animals
  • 32 Biomedical and clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kurokawa, M., & Kornbluth, S. (2009). Caspases and kinases in a death grip. Cell, 138(5), 838–854. https://doi.org/10.1016/j.cell.2009.08.021
Kurokawa, Manabu, and Sally Kornbluth. “Caspases and kinases in a death grip.Cell 138, no. 5 (September 2009): 838–54. https://doi.org/10.1016/j.cell.2009.08.021.
Kurokawa M, Kornbluth S. Caspases and kinases in a death grip. Cell. 2009 Sep;138(5):838–54.
Kurokawa, Manabu, and Sally Kornbluth. “Caspases and kinases in a death grip.Cell, vol. 138, no. 5, Sept. 2009, pp. 838–54. Epmc, doi:10.1016/j.cell.2009.08.021.
Kurokawa M, Kornbluth S. Caspases and kinases in a death grip. Cell. 2009 Sep;138(5):838–854.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

ISSN

0092-8674

Publication Date

September 2009

Volume

138

Issue

5

Start / End Page

838 / 854

Related Subject Headings

  • Phosphotransferases
  • Phosphorylation
  • Phosphoric Monoester Hydrolases
  • Humans
  • Developmental Biology
  • Cell Cycle
  • Caspases
  • Apoptosis
  • Animals
  • 32 Biomedical and clinical sciences