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The apoptosome: physiological, developmental, and pathological modes of regulation.

Publication ,  Journal Article
Schafer, ZT; Kornbluth, S
Published in: Developmental cell
May 2006

Apoptosis, a form of programmed cell death, is executed by a family of zymogenic proteases known as caspases, which cleave an array of intracellular substrates in the dying cell. Many proapoptotic stimuli trigger cytochrome c release from mitochondria, promoting the formation of a complex between Apaf-1 and caspase-9 in a caspase-activating structure known as the apoptosome. In this review, we describe knockout and knockin studies of apoptosome components, elegant structural and biochemical experiments, and analyses of the apoptosome in various cancers and other disease states, all of which have provided new insight into this critical locus of apoptotic control.

Duke Scholars

Published In

Developmental cell

DOI

EISSN

1878-1551

ISSN

1534-5807

Publication Date

May 2006

Volume

10

Issue

5

Start / End Page

549 / 561

Related Subject Headings

  • Humans
  • Gene Expression Regulation, Developmental
  • Disease
  • Developmental Biology
  • Biological Evolution
  • Apoptosis
  • Animals
  • 3101 Biochemistry and cell biology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Schafer, Z. T., & Kornbluth, S. (2006). The apoptosome: physiological, developmental, and pathological modes of regulation. Developmental Cell, 10(5), 549–561. https://doi.org/10.1016/j.devcel.2006.04.008
Schafer, Zachary T., and Sally Kornbluth. “The apoptosome: physiological, developmental, and pathological modes of regulation.Developmental Cell 10, no. 5 (May 2006): 549–61. https://doi.org/10.1016/j.devcel.2006.04.008.
Schafer ZT, Kornbluth S. The apoptosome: physiological, developmental, and pathological modes of regulation. Developmental cell. 2006 May;10(5):549–61.
Schafer, Zachary T., and Sally Kornbluth. “The apoptosome: physiological, developmental, and pathological modes of regulation.Developmental Cell, vol. 10, no. 5, May 2006, pp. 549–61. Epmc, doi:10.1016/j.devcel.2006.04.008.
Schafer ZT, Kornbluth S. The apoptosome: physiological, developmental, and pathological modes of regulation. Developmental cell. 2006 May;10(5):549–561.
Journal cover image

Published In

Developmental cell

DOI

EISSN

1878-1551

ISSN

1534-5807

Publication Date

May 2006

Volume

10

Issue

5

Start / End Page

549 / 561

Related Subject Headings

  • Humans
  • Gene Expression Regulation, Developmental
  • Disease
  • Developmental Biology
  • Biological Evolution
  • Apoptosis
  • Animals
  • 3101 Biochemistry and cell biology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences