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Mitochondria in apoptosis and human disease.

Publication ,  Journal Article
Olson, M; Kornbluth, S
Published in: Current molecular medicine
March 2001

Apoptosis is a process of cell suicide whereby individual cells are destroyed while preserving the integrity and architecture of surrounding tissue. This targeted cell destruction is critical both in physiological contexts as well as pathological states. It seems increasingly evident that mitochondria play an important role in the regulation of programmed cell death via release of proapoptotic agents and/or disruption of cellular energy metabolism. The mechanisms of mitochondrial involvement are beginning to be elucidated, and may involve the participation of bcl-2 family members, reactive oxygen species, and caspases. As part of a central mechanism of amplification of the apoptotic signal, mitochondria may be an appropriate target for therapeutic agents designed to modulate apoptosis. This review focuses on recent advances in understanding mitochondrial mechanisms in apoptosis and the involvement of these pathways in human disease.

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Published In

Current molecular medicine

DOI

EISSN

1875-5666

ISSN

1566-5240

Publication Date

March 2001

Volume

1

Issue

1

Start / End Page

91 / 122

Related Subject Headings

  • Proto-Oncogene Proteins c-bcl-2
  • Permeability
  • Models, Biological
  • Mitochondria
  • Membrane Potentials
  • Lipid Metabolism
  • Immunology
  • Humans
  • Disease
  • Cytochrome c Group
 

Citation

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Olson, M., & Kornbluth, S. (2001). Mitochondria in apoptosis and human disease. Current Molecular Medicine, 1(1), 91–122. https://doi.org/10.2174/1566524013364239
Olson, M., and S. Kornbluth. “Mitochondria in apoptosis and human disease.Current Molecular Medicine 1, no. 1 (March 2001): 91–122. https://doi.org/10.2174/1566524013364239.
Olson M, Kornbluth S. Mitochondria in apoptosis and human disease. Current molecular medicine. 2001 Mar;1(1):91–122.
Olson, M., and S. Kornbluth. “Mitochondria in apoptosis and human disease.Current Molecular Medicine, vol. 1, no. 1, Mar. 2001, pp. 91–122. Epmc, doi:10.2174/1566524013364239.
Olson M, Kornbluth S. Mitochondria in apoptosis and human disease. Current molecular medicine. 2001 Mar;1(1):91–122.

Published In

Current molecular medicine

DOI

EISSN

1875-5666

ISSN

1566-5240

Publication Date

March 2001

Volume

1

Issue

1

Start / End Page

91 / 122

Related Subject Headings

  • Proto-Oncogene Proteins c-bcl-2
  • Permeability
  • Models, Biological
  • Mitochondria
  • Membrane Potentials
  • Lipid Metabolism
  • Immunology
  • Humans
  • Disease
  • Cytochrome c Group